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. Author manuscript; available in PMC: 2013 Dec 15.
Published in final edited form as: J Immunol. 2012 Nov 7;189(12):5841–5848. doi: 10.4049/jimmunol.1201679

Figure 3. IFNAR mice can clear a secondary VACCINIA VIRUS infection non-specifically by 72 hours following a primary LCMV infection.

Figure 3

Type I IFN receptor knockout mice (IFNAR) were infected with LCMV clone 13 (c) and co-infected either on day 2 or 3 (the day is indicated in parentheses) with 1×104 pfu of Vaccinia virus (v). Vaccinia specific B8R responses were measured in the spleen 30 days following co-infection. A. % IFNγ+ CD8 cells. IFNAR mice were infected with LCMV clone 13 and infected with Vaccinia virus 3 days later. Mice were sacrificed 6 days following VACCINIA VIRUS infection and, B. VACCINIA VIRUS titers in the ovaries and VACCINIA VIRUS specific B8R responses were measured in the spleen, C. % IFNγ+ CD8 cells. D. Representative dot plot of B8R specific IFNγ producing CD8 cells. Data are representative of four to five mice per group and of two to three individual experiments with similar results. Error bars represent mean + SD. Statistics were analyzed by student two-tailed t-Test.