Figure 5. The nonspecific clearance of Vaccinia is dependent on IFNγ.

Wild type mice were infected with LCMV clone 13 at 2×10⁶ pfu i.v. Mice were co-infected with Vaccinia on day 3. Six days after co-infection mice were sacrificed. A. Levels of Vaccinia in ovaries by standard plaque assay. B. % Vaccinia B8R IFNγ producing cells in the spleen. C. Day 1 and 2 post clone 13 infection IFN-I bioactivity as measured by the standard IFN-I bioassay white bars are untreated and grey bars are anti-IFNγ treated. Error bars represent mean + SD. Two independent experiments combined n=8–10/group. Statistics performed using the two tailed students t-Test.