Skip to main content
. Author manuscript; available in PMC: 2013 Dec 15.
Published in final edited form as: J Immunol. 2012 Nov 7;189(12):5841–5848. doi: 10.4049/jimmunol.1201679

Figure 7. The in vivo antiviral state is dependent on CD8+ T cells.

Figure 7

Wild type mice were infected with LCMV clone 13 (c). Three days later some mice were co-infected with vaccinia virus (c+v). Some mice were treated with the NK depleting antibody (PK136) on day’s 0 and 3 post LCMV infection. A, Vaccinia virus titers in the ovaries and B, % CD8+ T cell response to the dominant vaccinia epitope B8R responses. Some infected mice were treated at the time of LCMV infection with anti-CD4 antibody (GK1.5) and C. Vaccinia virus titers in the ovaries and D, CD8+ T cell response to the vaccinia epitope B8R responses. Some mice were treated with anti-CD8 antibody (2.43) on day’s 0 and 3 post LCMV infection and E, Vaccinia virus titers in the ovary measured. F. Type I IFN bioactivity was measured day 2 post clone 13 infection. Plots represent the combined data from at least 2 independent experiments. Error bars represent mean + SD. Population distributions were compared by nonparametric two-tailed student t-Test.