Table 1.

Association between obesity-related variants and risk of contralateral breast cancer in the WECARE Study

SNP	Gene	Chr	Coordinate	Alleles	MAFa	HWEb	RRc	95% CI	P value
rs182052	ADIPOQ	3	188043475	G>A	0.35	0.88	1.0	0.8, 1.1	0.59
rs16861205	ADIPOQ	3	188044327	G>A	0.07	0.62	0.9	0.7, 1.2	0.61
rs822391	ADIPOQ	3	188046496	T>C	0.2	0.42	1.0	0.8, 1.2	0.83
rs16861210	ADIPOQ	3	188049191	G>A	0.09	0.16	1.0	0.8, 1.3	0.97
rs822394	ADIPOQ	3	188049421	C>A	0.19	0.35	1.0	0.9, 1.3	0.75
rs12495941	ADIPOQ	3	188050873	G>T	0.34	0.68	1.1	0.9, 1.3	0.16
rs7649121	ADIPOQ	3	188051478	A>T	0.18	0.55	1.0	0.8, 1.2	0.77
rs9877202	ADIPOQ	3	188052300	A>G	0.001	0.97	0.5	0.1, 5.1	0.54
rs17366568	ADIPOQ	3	188053146	G>A	0.13	0.31	0.9	0.7, 1.1	0.39
rs1501299	ADIPOQ	3	188053816	C>A	0.27	0.79	1.1	0.9, 1.3	0.18
rs3821799	ADIPOQ	3	188054179	C>T	0.47	0.56	0.9	0.8, 1.1	0.19
rs3774261	ADIPOQ	3	188054252	G>A	0.4	0.28	1.0	0.9, 1.2	0.80
rs17366743	ADIPOQ	3	188054782	T>C	0.03	0.14	0.8	0.5, 1.2	0.28
rs1063539	ADIPOQ	3	188058085	G>C	0.13	0.24	0.9	0.8, 1.2	0.57
rs7539542	ADIPOR1	1	201176596	C>G	0.33	0.22	1.1	0.9, 1.2	0.51
rs2275735	ADIPOR1	1	201182177	G>A	0.04	0.67	0.8	0.5, 1.2	0.30
rs12045862	ADIPOR1	1	201183428	C>T	0.28	0.34	1.0	0.8, 1.2	0.90
rs12733285	ADIPOR1	1	201188662	C>T	0.3	0.39	1.0	0.9, 1.2	0.90
rs10494839	ADIPOR1	1	201188816	T>C	0.29	0.92	1.0	0.8, 1.1	0.65
rs10753929	ADIPOR1	1	201189800	C>T	0.12	0.70	1.1	0.9, 1.4	0.31
rs12132093	ADIPOR1	1	201192735	G>A	0.009	0.76	1.4	0.7, 3.0	0.34
rs7514221	ADIPOR1	1	201193135	T>C	0.42	0.66	1.1	0.9, 1.3	0.39
rs11061925	ADIPOR2	12	1673494	C>T	0.32	0.49	1.0	0.8, 1.1	0.71
rs11061935	ADIPOR2	12	1684034	A>G	0.15	0.62	1.0	0.8, 1.2	0.69
rs7975600	ADIPOR2	12	1685512	A>T	0.16	0.90	1.0	0.8, 1.2	0.81
rs12826079	ADIPOR2	12	1696816	C>T	0.08	0.57	0.8	0.6, 1.1	0.27
rs11061946	ADIPOR2	12	1698787	C>T	0.07	0.33	1.1	0.8, 1.5	0.54
rs10773984	ADIPOR2	12	1701553	G>A	0.02	0.08	1.2	0.7, 1.9	0.49
rs11612383	ADIPOR2	12	1701615	G>A	0.32	0.91	1.0	0.8, 1.1	0.62
rs1058322	ADIPOR2	12	1707239	C>T	0.33	0.82	1.0	0.9, 1.2	0.95
rs9300298	ADIPOR2	12	1736455	T>A	0.5	0.11	1.0	0.8, 1.1	0.68
rs7967137	ADIPOR2	12	1740785	T>C	0.14	0.46	1.1	0.8, 1.3	0.69
rs12828908	ADIPOR2	12	1749645	A>G	0.33	0.02	1.0	0.8, 1.1	0.52
rs11061979	ADIPOR2	12	1752849	T>G	0.02	0.77	0.7	0.4, 1.1	0.13
rs12829901	ADIPOR2	12	1753638	G>A	0.02	0.47	0.6	0.3, 1.1	0.09
rs4140993	ADIPOR2	12	1759542	A>C	0.006	0.83	0.4	0.1, 1.3	0.14
rs12824519	ADIPOR2	12	1761788	G>A	0.02	0.47	0.6	0.3, 1.1	0.08
rs1044471	ADIPOR2	12	1767216	C>T	0.47	0.00	1.0	0.9, 1.2	0.70
rs9532558	FOXO1	13	40031014	T>C	0.02	0.37	0.5	0.3, 0.9	0.03
rs2755209	FOXO1	13	40035803	A>C	0.39	0.97	1.1	0.9, 1.3	0.33
rs2721068	FOXO1	13	40037711	T>C	0.26	0.82	1.0	0.9, 1.2	0.73
rs2180961	FOXO1	13	40038043	T>A	0.16	0.11	1.1	0.9, 1.3	0.47
rs2755212	FOXO1	13	40041147	T>C	0.01	0.69	1.0	0.5, 2.1	0.98
rs2755213	FOXO1	13	40044300	T>C	0.1	0.31	0.9	0.7, 1.2	0.49
rs2701870	FOXO1	13	40053775	G>C	0.07	0.84	0.9	0.7, 1.3	0.70
rs2951787	FOXO1	13	40059769	C>T	0.4	0.17	0.9	0.8, 1.1	0.46
rs2984121	FOXO1	13	40059978	C>G	0.18	0.74	1.0	0.8, 1.2	0.75
rs4429172	FOXO1	13	40087142	C>A	0.31	0.79	1.0	0.9, 1.2	0.74
rs12876443	FOXO1	13	40094876	T>C	0.1	0.00	1.1	0.9, 1.4	0.48
rs12866643	FOXO1	13	40110731	A>C	0.01	0.60	1.3	0.7, 2.4	0.36
rs12874490	FOXO1	13	40115733	G>C	0.01	0.72	2.1	1.1, 3.8	0.02
rs1334241	FOXO1	13	40121109	G>A	0.21	0.34	1.1	0.9, 1.3	0.44
rs9549248	FOXO1	13	40121395	A>G	0.002	0.93	0.0		0.98
rs9603776	FOXO1	13	40121885	C>T	0.03	0.01	1.1	0.7, 1.8	0.74
rs2297627	FOXO1	13	40131930	T>C	0.31	0.80	1.0	0.9, 1.2	0.63
rs6499640	FTO	16	52327177	A>G	0.41	0.31	0.9	0.8, 1.1	0.24
rs9940646	FTO	16	52358129	C>G	0.42	0.81	1.1	0.9, 1.3	0.34
rs1421085	FTO	16	52358454	T>C	0.39	0.94	1.1	0.9, 1.3	0.31
rs1121980	FTO	16	52366747	C>T	0.42	0.93	1.1	0.9, 1.3	0.35
rs8050136	FTO	16	52373775	C>A	0.39	0.75	1.1	0.9, 1.3	0.33
rs9939609	FTO	16	52378027	T>A	0.39	0.70	1.1	0.9, 1.3	0.31
rs16952624	FTO	16	52480338	C>T	0.004	0.99	0.0		0.98
rs7190492	FTO	16	53828752	G>A	0.37	0.51	1.0	0.9, 1.2	0.94
rs1111875	HHEX	10	94452861	G>A	0.41	0.94	1.0	0.8, 1.1	0.61
rs5015480	HHEX	10	94455538	C>T	0.41	0.99	1.0	0.8, 1.1	0.63
rs1951795	HIF1A	14	61241178	C>A	0.18	0.65	1.0	0.8, 1.2	0.82
rs10135579	HIF1A	14	61242939	A>G	0.05	0.01	0.8	0.6, 1.1	0.21
rs10129270	HIF1A	14	61251706	G>A	0.06	0.17	1.0	0.7, 1.4	0.98
rs4899056	HIF1A	14	61259283	C>T	0.1	0.37	1.0	0.8, 1.2	0.79
rs17099141	HIF1A	14	61263991	G>A	0.02	0.45	0.7	0.4, 1.2	0.23
rs2301111	HIF1A	14	61269953	C>G	0.2	0.54	1.0	0.9, 1.3	0.69
rs966824	HIF1A	14	61270270	C>T	0.04	0.47	1.0	0.7, 1.5	0.98
rs8012370	HIF1A	14	61274047	G>C	0.006	0.83	0.8	0.3, 2.1	0.57
rs10138153	HIF1A	14	61274927	C>T	0.006	0.83	0.8	0.3, 2.1	0.57
rs2301113	HIF1A	14	61276300	A>C	0.22	0.65	1.0	0.8, 1.2	0.99
rs11549465	HIF1A	14	61277309	C>T	0.1	0.63	1.1	0.9, 1.4	0.36
rs7143164	HIF1A	14	62166755	G>C	0.09	0.38	0.9	0.7, 1.2	0.63
rs9912108	IGF2BP1	17	44437242	T>C	0.0004	0.99	1.5	0.1, 26.0	0.76
rs17635703	IGF2BP1	17	44443154	A>C	0.05	0.81	1.0	0.7, 1.3	0.77
rs6504592	IGF2BP1	17	44445296	C>G	0.06	0.01	0.8	0.6, 1.1	0.24
rs9906710	IGF2BP1	17	44446281	C>A	0.36	0.36	1.1	0.9, 1.3	0.34
rs17708997	IGF2BP1	17	44457036	A>G	0.09	0.34	1.2	0.9, 1.6	0.13
rs8073244	IGF2BP1	17	44470036	C>T	0.15	0.68	1.1	0.9, 1.3	0.63
rs11872073	IGF2BP1	17	44474133	G>A	0.03	0.22	0.6	0.4, 1.1	0.10
rs4265867	IGF2BP1	17	44478822	G>A	0.02	0.40	1.2	0.7, 1.9	0.54
rs2969	IGF2BP1	17	44483245	C>T	0.26	0.70	0.9	0.8, 1.1	0.50
rs11655950	IGF2BP1	17	44484119	G>A	0.32	0.98	1.1	0.9, 1.3	0.43
rs3744085	IGF2BP1	17	44486899	T>C	0.49	0.10	1.1	0.9, 1.2	0.45
rs4402960	IGF2BP2	3	186994380	G>T	0.33	0.06	1.0	0.9, 1.2	0.88
rs9515119	IRS2	13	109207336	A>C	0.33	0.08	0.9	0.8, 1.1	0.28
rs7996317	IRS2	13	109207931	A>C	0.0008	0.98	1.0	0.1, 6.4	0.96
rs754204	IRS2	13	109209568	C>T	0.48	0.72	1.0	0.9, 1.2	0.65
rs913949	IRS2	13	109209796	A>G	0.19	0.78	1.1	0.9, 1.3	0.60
rs12583454	IRS2	13	109214505	G>A	0.02	0.59	0.6	0.4, 1.1	0.12
rs2241745	IRS2	13	109220531	A>G	0.14	0.46	1.1	0.9, 1.4	0.43
rs9559648	IRS2	13	109221795	C>T	0.31	0.71	1.0	0.9, 1.2	0.82
rs7323191	IRS2	13	109222075	A>T	0.15	0.07	1.1	0.8, 1.3	0.66
rs7999797	IRS2	13	109224000	A>G	0.46	0.32	1.0	0.8, 1.1	0.69
rs11841502	IRS2	13	109225988	G>A	0.34	0.31	1.0	0.9, 1.2	0.79
rs7997595	IRS2	13	109228768	C>G	0.15	0.55	1.1	0.9, 1.3	0.56
rs11618950	IRS2	13	109232310	G>A	0.17	0.20	1.0	0.8, 1.2	0.88
rs4773092	IRS2	13	109233953	G>A	0.4	0.79	1.1	0.9, 1.3	0.19
rs4731426	LEP	7	127669305	C>G	0.47	0.62	0.9	0.8, 1.1	0.34
rs11763517	LEP	7	127677297	T>C	0.5	0.74	1.0	0.9, 1.2	0.98
rs11760956	LEP	7	127678322	G>A	0.39	0.12	1.0	0.8, 1.1	0.54
rs3828942	LEP	7	127681540	G>A	0.42	0.69	1.0	0.9, 1.15	0.91
rs17151919	LEP	7	127681827	G>A	0.0008	0.98	0.0		0.98
rs12145690	LEPR	1	65659600	A>C	0.45	0.26	1.1	0.9, 1.2	0.54
rs4655802	LEPR	1	65660818	A>G	0.41	0.10	1.0	0.8, 1.1	0.69
rs9436739	LEPR	1	65663286	T>A	0.13	0.79	1.0	0.8, 1.2	0.81
rs9436298	LEPR	1	65663770	T>A	0.007	0.81	0.6	0.2, 1.9	0.41
rs9436740	LEPR	1	65664488	A>T	0.28	0.43	1.1	0.9, 1.3	0.49
rs3790433	LEPR	1	65666929	G>A	0.26	0.48	1.1	0.9, 1.3	0.33
rs9436303	LEPR	1	65669261	A>G	0.25	0.27	1.0	0.8, 1.2	0.94
rs1045895	LEPR	1	65670568	G>A	0.4	0.45	0.8	0.7, 1.0	0.01
rs1536466	LEPR	1	65671559	T>C	0.005	0.85	0.3	0.1, 1.2	0.09
rs10889552	LEPR	1	65678760	C>T	0.05	0.15	1.2	0.9, 1.7	0.25
rs970468	LEPR	1	65679077	T>G	0.36	0.66	1.2	1.0, 1.4	0.07
rs970467	LEPR	1	65679349	G>A	0.12	0.92	1.0	0.8, 1.3	0.73
rs17127652	LEPR	1	65707730	A>G	0.02	0.55	1.4	0.8, 2.4	0.24
rs6704167	LEPR	1	65710467	A>T	0.45	0.62	0.8	0.7, 1.0	0.01
rs7518849	LEPR	1	65721378	T>C	0.07	0.28	1.2	0.9, 1.6	0.17
rs6694528	LEPR	1	65735603	C>T	0.13	0.19	1.1	0.9, 1.4	0.25
rs7537093	LEPR	1	65739151	A>G	0.49	0.28	0.8	0.7, 1.0	0.02
rs6672331	LEPR	1	65748434	G>C	0.03	0.28	1.2	0.7, 1.8	0.54
rs11208659	LEPR	1	65751867	T>C	0.09	0.86	1.2	0.9, 1.5	0.16
rs1627238	LEPR	1	65758666	C>T	0.18	0.95	1.0	0.8, 1.2	0.93
rs1171279	LEPR	1	65761080	C>T	0.27	0.75	1.1	0.9, 1.3	0.43
rs1171267	LEPR	1	65776441	G>T	0.34	0.42	1.2	1.0, 1.4	0.03
rs1137100	LEPR	1	65809028	A>G	0.25	0.59	1.1	1.0, 1.4	0.13
rs3790429	LEPR	1	65809363	A>T	0.18	0.04	1.0	0.8, 1.2	0.70
rs13306519	LEPR	1	65810516	C>G	0.004	0.88	1.4	0.4, 4.3	0.59
rs6588152	LEPR	1	65811585	T>A	0.22	0.76	1.0	0.8, 1.2	0.69
rs6673591	LEPR	1	65820976	G>A	0.52	0.20	0.9	0.8, 1.1	0.21
rs1137101	LEPR	1	65831100	A>G	0.43	0.29	1.1	0.9, 1.3	0.32
rs4655537	LEPR	1	65831388	G>A	0.37	0.01	0.9	0.8, 1.1	0.47
rs3762274	LEPR	1	65836700	A>G	0.38	0.38	1.1	0.9, 1.2	0.56
rs17097193	LEPR	1	65839983	T>C	0.03	0.08	1.1	0.7, 1.7	0.58
rs11585329	LEPR	1	65846401	G>T	0.16	0.01	1.0	0.8, 1.3	0.78
rs8179183	LEPR	1	65848539	G>C	0.18	0.59	1.0	0.8, 1.2	0.68
rs12040007	LEPR	1	65852747	G>A	0.18	0.60	1.1	0.9, 1.3	0.43
rs4655557	LEPR	1	65853374	T>C	0.38	0.12	1.1	0.9, 1.2	0.52
rs17127832	LEPR	1	65869512	T>C	0.19	0.16	1.0	0.8, 1.2	0.91
rs17700144	MC4R	18	55962961	G>A	0.2	0.78	1.1	0.9, 1.3	0.43
rs17782313	MC4R	18	56002076	T>C	0.21	0.40	1.1	0.9, 1.3	0.47
rs12970134	MC4R	18	56035729	G>A	0.24	0.97	1.1	0.9, 1.3	0.51
rs17700633	MC4R	18	56080411	G>A	0.28	0.50	1.0	0.9, 1.2	0.80
rs2229616	MC4R	18	56190255	G>A	0.02	0.07	1.1	0.7, 1.8	0.66
rs8087522	MC4R	18	56191457	G>A	0.31	0.45	1.2	1.0, 1.4	0.03
rs3101336	NEGR1	1	72523772	G>A	0.38	0.48	1.1	0.9, 1.2	0.49
rs2568958	NEGR1	1	72537703	A>G	0.38	0.52	1.1	0.9, 1.2	0.44
rs2815752	NEGR1	1	72585027	T>C	0.38	0.46	1.1	0.9, 1.2	0.49
rs2227562	PLAU	10	75342966	G>A	0.15	0.41	1.2	1.0, 1.5	0.04
rs2227564	PLAU	10	75343106	C>T	0.24	0.53	1.1	0.9, 1.3	0.21
rs4065	PLAU	10	75346469	T>C	0.43	0.53	1.2	1.1, 1.4	0.01
rs344783	PLAUR	19	34997734	C>T	0.48	0.15	1.0	0.9, 1.2	0.93
rs4251938	PLAUR	19	48843460	A>G	0.12	0.04	0.9	0.7, 1.2	0.43
rs2302524	PLAUR	19	48848311	T>C	0.16	0.09	1.0	0.8, 1.2	0.75
rs4251871	PLAUR	19	48853337	G>C	0.05	0.52	1.0	0.7, 1.4	0.96
rs4251864	PLAUR	19	48854072	T>C	0.09	0.94	1.1	0.8, 1.4	0.60
rs2239372	PLAUR	19	48854793	G>A	0.5	0.76	1.0	0.9, 1.1	0.83
rs2283628	PLAUR	19	48854900	T>C	0.18	0.31	1.1	0.9, 1.3	0.32
rs397374	PLAUR	19	48855620	A>T	0.22	0.76	1.1	0.9, 1.3	0.30
rs2283632	PLAUR	19	48856930	G>A	0.11	0.11	1.1	0.8, 1.3	0.68
rs4251831	PLAUR	19	48861577	G>C	0.29	0.96	0.9	0.8, 1.1	0.18
rs2286960	PLAUR	19	48863864	C>T	0.24	0.70	1.0	0.9, 1.2	0.83
rs1801282	PPARG	3	12368124	C>G	0.12	0.13	1.0	0.8, 1.3	0.97
rs6092	SERPINE1	7	100558436	G>A	0.11	0.34	0.9	0.7, 1.2	0.61
rs2227666	SERPINE1	7	100561424	G>A	0.05	0.77	1.3	0.9, 1.8	0.18
rs2227712	SERPINE1	7	100563672	G>A	0.003	0.91	0.8	0.2, 3.1	0.78
rs2070682	SERPINE1	7	100563986	T>C	0.44	0.52	1.0	0.9, 1.2	0.61
rs2227692	SERPINE1	7	100565963	C>T	0.08	0.12	0.8	0.6, 1.1	0.22
rs1050813	SERPINE1	7	100568334	G>A	0.21	0.09	1.0	0.9, 1.2	0.83
rs2227714	SERPINE1	7	100568628	C>T	0.05	0.82	1.1	0.8, 1.6	0.51
rs7903146	TCF7L2	10	114748338	C>T	0.29	0.87	0.9	0.8, 1.1	0.42
rs2867125	TMEM18	2	612826	G>A	0.19	0.81	0.9	0.8, 1.1	0.53
rs6548238	TMEM18	2	624904	C>T	0.19	0.67	1.0	0.8, 1.2	0.83
rs4854344	TMEM18	2	628143	T>G	0.19	0.73	1.0	0.8, 1.2	0.85
rs7561317	TMEM18	2	634952	G>A	0.19	0.81	1.0	0.8, 1.2	0.81
rs10168696	TMEM18	2	662495	T>C	0.14	0.88	1.0	0.8, 1.2	0.76
rs2293084	TMEM18	2	665830	C>A	0.46	0.42	1.1	0.9, 1.2	0.50
rs2293083	TMEM18	2	666176	C>G	0.26	0.44	0.9	0.7, 1.0	0.07

Abbreviations: SNP=single nucleotide polymorphism; Chr=chromosome; MAF=minor allele frequency; HWE=Hardy-Weinberg equilibrium; RR=rate ratio; 95% CI=95% confidence interval

^aMAF in UBC controls

^bHWE in UBC controls, p<0.001

^cPer allele RR (log-additive model) adjusting for age at diagnosis and the counter-matching offset term