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. 2012 Aug 30;23(1):45–59. doi: 10.1111/j.1750-3639.2012.00616.x

Figure 3.

figure

27‐ 32‐ and 34‐week fetal TSC brain. A–C. Fetal brain (27 GW) with a focal lesion consisting of giant cells and germinal matrix cells (arrows) in the deep white matter adjacent to the germinal matrix. D–F. Fetal brain (32 GW) with multiple lesions consisting of giant cells. These cells were located in the deep white matter and often arranged in longitudinal cell clusters (F). H and I. Fetal brain (H, 34 GW; I, 38 GW) showing disorganized cortical lamination with abnormal cell types, including large, bizarre neuroglial cells with the appearance of giant cells (arrows indicate giant cells in the subpial region, molecular zone). J. High magnification of giant cells; insert in J shows positivity for nestin (38 GW). Scale bar (in A): A: 5 mm; B, D: 500 μm; C, E: 250 μm; F–I: 125 μm; J: 50 μm. CP = cortical plate; GW = gestational week; TSC = tuberous sclerosis complex; VZ = ventricular zone.