Table 2.

Increase in BMI per Increment of 10 Risk Alleles, According to Intake of Sugar-Sweetened and Artificially Sweetened Beverages in the NHS and HPFS Cohorts.^*

Analysis	Increase in BMI				P Value for Interaction
	<1 Serving per Month	1–4 Servings per Month	2–6 Servings per Week	≥1 Serving per Day
Sugar-sweetened beverages
NHS cohort
Model 1†	1.17±0.18	1.66±0.16	1.84±0.23	2.12±0.39	0.004
Model 2‡	1.18±0.17	1.56±0.16	1.78±0.22	2.03±0.38	0.008
HPFS cohort
Model 1†	0.80±0.20	0.42±0.21	1.05±0.19	1.59±0.37	0.06
Model 2‡	0.77±0.19	0.43±0.20	1.08±0.19	1.54±0.37	0.02
Pooled cohorts§
Model 1†	1.00±0.13	1.20±0.13	1.37±0.15	1.85±0.27	<0.001
Model 2‡	1.00±0.13	1.12±0.12	1.38±0.14	1.78±0.27	<0.001
Artificially sweetened beverages
NHS cohort
Model 1†	1.43±0.20	1.37±0.21	1.43±0.20	1.42±0.29	0.88
Model 2‡	1.42±0.18	1.25±0.21	1.39±0.20	1.36±0.27	0.91
HPFS cohort
Model 1†	0.94±0.18	0.78±0.24	0.40±0.20	1.04±0.31	0.63
Model 2‡	0.95±0.18	0.76±0.23	0.45±0.20	0.92±0.29	0.46
Pooled cohorts§
Model 1†	1.16±0.13	1.11±0.16	0.92±0.14	1.24±0.21	0.83
Model 2‡	1.19±0.13	1.03±0.16	0.92±0.14	1.16±0.20	0.64

^*Plus–minus values are β coefficients ±SE. Data were derived from repeated-measures analysis for women in the NHS (five measures during the period from 1980 to 1998) and for men in the HPFS (three measures during the period from 1986 to 1998). Data on beverage intake were assessed 4 years before the assessment of BMI.

^†Data were adjusted for age and source of genotyping data.

^‡Data were further adjusted for level of physical activity, time spent watching television, status with respect to current smoking, alcohol intake, Alternative Healthy Eating Index score, and total energy intake.

^§Results for the two cohorts were pooled by means of inverse-variance–weighted, fixed-effects meta-analyses.