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. 2012 Oct 19;1(5-6):249–261. doi: 10.1007/s40037-012-0029-9

Table 4.

Examples of clinical questions answered by evidence-based case reports

Clinical questions Type of question
University of Indonesia
 Is artemether–lumefantrine (AL) as effective as artesunate–amodiaquine (ASAD; standard treatment of malaria therapy in Indonesia) for treating uncomplicated childhood malaria? Therapy
 Mortality after balloon aortic valvuloplasty in male with severe aortic stenosis Prognosis
 Is the nitrite test accurate as diagnostic tool in pregnant women? Diagnosis
 In hospitalised elderly patients, is depression related to higher mortality? Prognosis
 Could calcium supplementation prevent osteoporotic fracture in post-menopausal women? Therapy
 Diagnostic value of abdominal radiography to diagnose acute appendicitis in children Diagnosis
 The effectiveness of normal saline solution vs Ringer’s lactate solution to overcome dengue shock syndrome in children Therapy
 Is acupuncture effective to decrease pain in patient with chronic back pain? Therapy
University of Malaya
 Is exercise stress echocardiography superior in diagnosing patients presenting with chest pain compared with exercise stress electrocardiography? Diagnosis
 Can Parkinson’s disease be treated more effectively by using dopamine agonists compared with levodopa in Parkinson patients above 50 years? Therapy
 Do colorectal cancer patients with high levels of tumour markers CEA and CA19-9 have a low 3-year survival rate? Prognosis
 Does the Revised Trauma Score (RTS) make a good prognostic tool in trauma patients? Prognosis
 Do children with past history of sexual abuse have increased risk of psychiatric problems in adulthood? Prognosis
University Medical Center Utrecht
 The prognostic value of a history of shoulder pain on predicting the duration of pain in patients presenting with a new episode of shoulder pain Prognosis
 The influence of physiotherapy on pain in patients with shoulder impingement Therapy
 Diagnostic ultrasound in a patient suspected of a partial rotator cuff rupture Diagnosis
 Does treatment with heparin in adults diagnosed with cerebral venous thrombosis reduce mortality within 3-months? Therapy
 CT venography: the new reference test for diagnosing cerebral venous thrombosis? Diagnosis
 Glasgow Coma Scale as a prognostic factor in sinus thrombosis Prognosis
 Prognostic value of current smoking for exacerbations in COPD Prognosis
 For patients with COPD in the primary care setting: what is the predictive value of CRP for community-acquired pneumonia? Prognosis
 Diagnostic value of BNP for determining chronic heart failure in patients with COPD Diagnosis