Table 3.
Multivariable Cox Regression Model of the Hazard of Subsequent Tuberculosis Among Subjects With Prior Active Tuberculosis
| Variable | No. | Hazard of Definite Tuberculosis | 95% CI for HR | P Value | Hazard of Definite/Probable Tuberculosis | 95% CI for HR | P Value |
|---|---|---|---|---|---|---|---|
| Univariate analyses | |||||||
| Age, each 10-year increment | 979 | 1.24 | .88–1.76 | .213 | 1.19 | .91–1.55 | .200 |
| Baseline CD4 count, each 100 cells/µL increment | 977 | 0.76 | .64–.90 | .002 | 0.68 | .59–.79 | <.001 |
| Baseline HIV RNA | 341 | 2.21 | 1.31–3.71 | .003 | 2.45 | 1.64–3.66 | <.001 |
| Baseline ART | 979 | 0 | a | 1.0 | 0 | a | 1.0 |
| TST positive | 961 | 2.44 | 1.40–4.26 | .002 | 1.78 | 1.17–2.69 | .007 |
| Prior active tuberculosis, unadjusted | 979 | 3.27 | 1.68–6.36 | <.001 | 2.82 | 1.66–4.77 | <.001 |
| Multivariable analyses | |||||||
| Prior active tuberculosis, adjusted for age, CD4 count, completed 180 days of INH | 977 | 3.69 | 1.79–7.63 | <.001 | 2.78 | 1.58–4.87 | <.001 |
| Prior active tuberculosis, adjusted for age, CD4 count, completed 180 days of INH, ART | 977 | 3.76 | 1.81–7.77 | <.001 | 2.85 | 1.62–5.01 | <.001 |
| Prior active tuberculosis, adjusted for age, CD4 count, completed 180 days of INH, HIV RNA | 341 | 3.93 | 1.47–10.50 | .006 | 3.31 | 1.55–7.08 | .002 |
| Prior active tuberculosis, adjusted for age, CD4 count, TST status | 959 | 2.99 | 1.50–5.95 | .002 | 2.54 | 1.48–4.36 | .001 |
| Prior active tuberculosis, adjusted for age, CD4 count, TST status, ART | 959 | 3.01 | 1.51–6.02 | .002 | 2.59 | 1.51–4.45 | .001 |
| Prior active tuberculosis, adjusted for age, CD4 count, TST status, ART, HIV RNA | 334 | 3.32 | 1.29–8.56 | .013 | 2.98 | 1.44–6.14 | .003 |
Abbreviations: ART, antiretroviral therapy; CI, confidence interval; HIV, human immunodeficiency virus; HR, hazard ratio; INH, isoniazid; TST, tuberculin skin test.
a No subjects on ART developed definite or definite/probable tuberculosis, such that 95% CIs cannot be calculated.