Table 4.
Multivariable Cox Regression Model of the Hazard of Subsequent Tuberculosis Among Subjects With Prior Active Tuberculosis Among the 703 Subjects Who Did Not Receive Isoniazid Preventive Therapy (78 With Prior Active Tuberculosis, 625 With No Prior Active Tuberculosis)
| Variable | No. | Hazard of Definite Tuberculosis | 95% CI for HR | P Value | Hazard of Definite/Probable Tuberculosis | 95% CI for HR | P Value |
|---|---|---|---|---|---|---|---|
| Univariate analyses | |||||||
| Age, each 10-year increment | 703 | 1.10 | .68–1.76 | .703 | 1.02 | .72–1.44 | .912 |
| Baseline CD4 count, each 100 cells/µL increment | 701 | 0.76 | .60–.96 | .020 | 0.66 | .54–.81 | <.001 |
| Baseline HIV RNA | 230 | 2.19 | 1.08–4.45 | .030 | 2.24 | 1.34–3.75 | .002 |
| Baseline ART | 703 | 0 | a | 1.0 | 0 | a | 1.0 |
| TST positive | 685 | 5.80 | 2.47–13.59 | <.001 | 3.53 | 1.72–7.22 | .001 |
| Prior active tuberculosis, unadjusted | 703 | 4.93 | 2.35–10.37 | <.001 | 3.31 | 1.86–5.91 | <.001 |
| Multivariable analyses | |||||||
| Prior active tuberculosis, adjusted for age, CD4 count | 701 | 4.79 | 2.23–10.28 | <.001 | 3.07 | 1.69–5.56 | <.001 |
| Prior active tuberculosis, adjusted for age, CD4 count, ART | 701 | 4.91 | 2.29–10.56 | <.001 | 3.15 | 1.74–5.73 | <.001 |
| Prior active tuberculosis, adjusted for age, CD4 count, ART, HIV RNA | 230 | 6.38 | 2.14–19.02 | .001 | 3.91 | 1.71–8.94 | .001 |
Abbreviations: ART, antiretroviral therapy; CI, confidence interval; HIV, human immunodeficiency virus; HR, hazard ratio; TST, tuberculin skin test.
a No subjects on ART developed definite or definite/probable tuberculosis, such that 95% CIs cannot be calculated.