Table 5.
Multivariable Cox Regression Model of the Hazard of Subsequent Tuberculosis Among 649 Subjects With a Negative Baseline Tuberculin Skin Test (47 With Prior Active Tuberculosis, 602 With No Prior Active Tuberculosis)
| Variable | No. | Hazard of Definite Tuberculosis | 95% CI for HR | P Value | Hazard of Definite/Probable Tuberculosis | 95% CI for HR | P Value |
|---|---|---|---|---|---|---|---|
| Univariate analyses | |||||||
| Age, each 10-year increment | 649 | 1.08 | .61–1.90 | .792 | 1.04 | .70–1.54 | .842 |
| Baseline CD4 count, each 100 cells/µL increment | 647 | 0.78 | .60–1.03 | .078 | 0.64 | .51–.81 | <.001 |
| Baseline HIV RNA | 207 | 1.94 | .86–4.36 | .109 | 2.29 | 1.26–4.17 | .006 |
| Baseline ART | 649 | 0 | a | 1.0 | 0 | a | 1.0 |
| Prior active tuberculosis, unadjusted | 649 | 3.26 | 1.10–9.66 | .033 | 3.07 | 1.43–6.60 | .004 |
| Multivariable analyses | |||||||
| Prior active tuberculosis, adjusted for age, CD4 count | 647 | 2.69 | .89–8.18 | .080 | 2.22 | 1.02–4.84 | .046 |
| Prior active tuberculosis, adjusted for age, CD4 count, ART | 647 | 2.85 | .94–8.66 | .064 | 2.34 | 1.07–5.12 | .033 |
| Prior active tuberculosis, adjusted for age, CD4 count, ART, HIV RNA | 207 | 2.84 | .58–13.90 | .198 | 2.88 | .93–8.93 | .067 |
Abbreviations: ART, antiretroviral therapy; CI, confidence interval; HIV, human immunodeficiency virus; HR, hazard ratio.
a No subjects on ART developed definite or definite/probable tuberculosis, such that 95% CIs cannot be calculated.