Table 1.

Characteristics of common variable immunodeficiency (CVID) patients involved in the study. Presence of bronchiectasis was determined by computerized tomography (CT) scan. Splenomegaly was defined in spleen length >11 cm in abdominal sonography. Natural killer (NK) cells were defined as CD3^–CD16/CD56⁺ cells

Patient no.	Age (years)	Sex	EUROclass classification	Chronic diarrhoea	Splenomegaly	Granuloma	Bronchiectasis	Dose IgG/kg/week	IgG through level (g/l)	Leucocytes (103/μl)	Lymphocytes (%)	Lymphocytes (103/μl)	CD3+ (103/μl)	CD3+CD4+ (103/μl)	CD3+CD8+ (103/μl)	CD19+ (103/μl)	NK cells (103/μl)	CD4+CD45RO+/CD4+(%)
1	33	F	smB-21lo	Yes	Yes	Yes	No	0.12	4.2	5.2	9	0.47	0.37	0.23	0.12	0.05	0.04	87
2	78	F	smB-21lo	No	Yes	No	Yes	0.12	6.66	5.1	36	1.84	1.36	0.55	0.66	0.39	0.07	86
3	59	F	smB-21lo	No	Yes	No	Yes	0.12	8.3	3.3	28	0.92	0.72	0.37	0.34	0.13	0.06	93
4	45	F	smB-21lo	No	Yes	No	Yes	0.08	5.32	8.3	25	2.08	1.58	0.87	0.62	0.39	0.08	80
5	68	F	smB-21lo	Yes	Yes	No	Yes	0.09	5.95	4.2	27	1.13	0.90	0.43	0.43	0.09	0.15	78
6	35	F	smB-21norm	No	No	No	No	0.10	6.95	5.9	25	1.48	1.19	0.65	0.52	0.04	0.24	47
7	40	F	ND	No	Yes	No	No	0.07	5.63	8.7	18	1.57	1.35	0.53	0.83	ND	0.22	85
8	22	F	smB-21lo	No	Yes	No	Yes	0.06	7.66	4.2	44	1.85	1.48	0.79	0.61	0.24	0.11	55
9	65	F	smB-21lo	No	No	No	No	0.10	6.61	7.4	21	1.55	0.93	0.56	0.31	0.30	0.30	70
10	55	F	smB-21lo	No	No	No	Yes	0.06	5.78	5.7	29	1.65	1.19	0.58	0.36	0.20	0.26	88
11	19	M	smB-21norm	No	No	No	No	0.09	5.2	4.4	25	1.10	0.84	0.39	0.39	0.17	0.10	70
12	58	F	smB-21lo	Yes	Yes	No	Yes	0.08	6.23	5.7	23	1.31	0.88	0.43	0.41	0.18	0.25	92
13	52	M	ND	Yes	Yes	Yes	Yes	0.10	6.37	15.4	4	0.62	0.49	0.26	0.19	ND	0.11	70
14	25	M	smb+21lo	No	No	No	No	NT	3.51	7.8	24	1.87	1.07	0.58	0.37	0.24	0.54	73
15	30	F	smB-21lo	Yes	No	No	Yes	0.07	5.56	2.7	30	0.81	0.76	0.58	0.18	0.02	0.02	36
16	51	M	smB-21lo	Yes	Yes	No	Yes	0.09	3.1	4.4	35	1.54	1.43	0.83	0.57	0.05	0.06	98
17	45	F	smB-21lo	No	Yes	No	No	0.10	3.07	6.4	12	0.77	0.62	0.25	0.37	0.07	0.07	85
18	29	F	smB-21norm	No	No	No	Yes	NT	2.35	7.0	24	1.68	0.99	0.60	0.32	0.55	0.12	68
19	35	M	smB-21norm	No	Yes	No	No	0.08	5.2	5.6	31	1.74	1.48	0.49	0.95	0.17	0.09	60
20	41	F	smB-21lo	No	Yes	No	Yes	0.11	6.33	7.6	28	2.13	1.66	0.83	0.66	0.32	0.13	58
21	58	M	smB-21lo	Yes	Yes	No	Yes	0.09	5.22	9.2	24	2.21	1.19	0.66	0.49	0.77	0.22	68
22	45	F	smB-21lo	No	No	No	Yes	0.11	6.06	5.6	45	2.52	2.24	0.86	1.21	0.20	0.03	75
23	51	F	ND	No	Yes	No	Yes	0.11	4.83	10.3	17	1.75	1.66	0.84	0.81	ND	0.09	91
24	72	F	smb+21lo	No	Yes	No	No	0.06	4.9	8.3	38	3.15	2.40	1.58	0.91	0.69	0.03	58
25	21	F	smB-21norm	No	Yes	Yes	Yes	0.08	6.4	4.4	18	0.79	0.62	0.38	0.20	0.13	0.02	86
26	42	F	smB+21norm	No	No	No	No	0.07	4.7	5.7	21	1.20	0.83	0.57	0.25	0.22	0.16	92
27	38	M	smB-21lo	No	Yes	Yes	No	0.09	5.73	5.2	18	0.94	0.85	0.43	0.42	0.03	0.03	88
28	51	F	smB-21lo	No	Yes	No	Yes	0.14	6.12	3.3	19	0.63	0.57	0.39	0.17	0.02	0.04	98
29	60	M	smB-21norm	Yes	Yes	No	No	0.06	6.26	4.9	19	0.93	0.59	0.42	0.13	0.19	0.14	75
30	41	F	smB-21lo	Yes	Yes	No	Yes	0.04	2.96	3.8	29	1.10	0.94	0.37	0.53	0.12	0.04	82
31	23	F	smB-21lo	No	Yes	No	No	0.06	4.5	9.0	31	2.79	2.32	1.42	0.67	0.33	0.11	52
32	51	M	smB-21lo	No	No	No	Yes	0.10	5.3	5.2	31	1.61	1.26	0.37	0.77	0.13	0.23	77
33	70	M	smB-21lo	No	Yes	Yes	No	0.05	4.49	4.7	18	0.85	0.76	0.43	0.36	0.02	0.06	98
34	29	F	smB-21lo	Yes	Yes	No	No	0.08	5.8	4.1	27	1.11	0.95	0.61	0.30	0.10	0.06	63
35	22	M	smB-21lo	Yes	Yes	No	No	0.07	4.43	6.1	37	2.26	1.31	0.50	0.84	0.23	0.70	81

NT: not treated; ND: not determined, the patient had B cells < 1% of total lymphocytes; F: female; M: male.