Figure 2.

Gadd45b^−/− mutants exhibit normal baseline behavior and elevated motor learning. A, Open field. No significant differences were found in horizontal activity (left), velocity (middle) or thigmotaxis (right). B, Elevated plus maze. No significant effect of genotype was found on open or closed arm entries (left) or total time spent in open and closed arms (right). C, Prepulse inhibition. No effect of genotype was found at 4, 8 or 16 dB prepulse intensities. D (Left) Shock threshold test. Similar thresholds to flinch, vocalize and jump were found between genotypes. (Right) Hot plate test. No significant difference in latency to lift or lick the animal's hindpaw was found. E, Accelerating rotarod. Mean latency of four trails per day over 3 d (left) and percentage of animals per genotype reaching 300 s maximum (right) are reported. Knock-outs showed significantly elevated performance on day 2 (p < 0.05). F, Accelerating rotarod on backcrossed mice. No significant (p > 0.05) effect of genotype was found (n = 7–15/group).