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. 2012 Nov 28;32(48):17059–17066. doi: 10.1523/JNEUROSCI.1747-12.2012

Figure 4.

Figure 4.

Facilitation of long-term potentiation in gadd45b−/− mutants. A–D, Field EPSP recordings from area CA1 before and after stimulation of Schaffer collaterals with listed paradigms. Stimuli were set to an intensity eliciting a fEPSP with 25% of the maximum slope in A and 50% in B–D. Mutant slices demonstrated enhanced LTP (p < 0.05) during the last 30 min of recording only after low-intensity induction. E, Input-output relationship of evoked fEPSP slope versus stimulus intensity in WT and KO slices revealed no effect of the mutation on baseline synaptic transmission. F, G, Paired-pulse facilitation studies across different interstimulus intervals revealed no effect of genotype when using normal-intensity stimuli (F) but a significant (p < 0.01) deficit in KOs under low-intensity stimuli (G) (n = 6–15 mice/group, 4–10 slices/mouse).