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Simulated effect of p.Val392Ile Kv4.3 on the left ventricular epicardial action potential. Left ventricular epicardial action potentials were simulated using wild-type (WT), p.Gly600Arg, and p.Val392Ile mutant Ito incorporated into a modified Luo–Rudy II AP model. BCL = 800 ms (75 bpm). Solid line, WT; dashed line, p.Gly600Arg; dotted line, p.Val392Ile. Only the 10th AP in the equilibration chain is displayed here, the AP shape does not change in subsequent cycles (BCL = 800 ms).
