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. Author manuscript; available in PMC: 2013 Aug 15.
Published in final edited form as: Int J Cancer. 2011 Oct 24;131(4):834–843. doi: 10.1002/ijc.26428

Figure 2. Targeting emmprin suppresses KSHV-induced, VEGF-dependent invasion for endothelial cells.

Figure 2

HUVEC were incubated with media (mock) or purified KSHV (K) for 2 h, in some cases following their transfection for 48 h with control siRNA (n-siRNA) or emmprin-siRNA (e-siRNA). Cells were subsequently incubated in fresh media for an additional 24 h prior to completion of transwell invasion assays in the presence or absence of 5 ng/mL recombinant human VEGF or 10 ng/mL recombinant human IL-6. Relative invasiveness was calculated as described in Methods. Error bars represent the S.E.M. for three independent experiments. ** = p<0.01.