Figure 4.

Evidence for related functional roles of neighboring Purkinje cells. (A) Schematic illustrating a surface view of the cerebellar cortex with red indicating possible patterns of convergent Purkinje cells. Converging Purkinje cells can be (top to bottom) widespread, clustered, on-beam, or ordered parasagittally. (B) Projections of two rat Purkinje cells that were separated transversely but located in the same aldolase C compartment. Two small injections were made in medial and lateral 5- in the apex of crus IIa. Purkinje cell axons that originated from each of the injections were reconstructed. Blue axons indicate those that were partially reconstructed, except for the fine branches in the terminal arbor. The medial Purkinje cells projected to the lateral anterior interpositus nucleus (AIN) while the lateral Purkinje cells projected to the junction between the dorsolateral hump (DLH) of the anterior interpositus and lateral anterior interpositus nucleus. Scale bar = 500 μm. Panel (B) reprinted from Sugihara et al. (2009), with permission. (C) Labeling of Purkinje after injection of rabies virus into various limb muscles of the rat. Microphotographs showing labeling of a cluster of Purkinje cells in the lateral vermis. Purkinje cells within such a cluster display a uniform level of infection. Scale bar: 100 μm. Panel (C) reprinted from Ruigrok et al. (2008), with permission.