Table 1. Distribution of acetaminophen use and risk of asthma at 2 - 8 years.
| Case n (%) | Control n (%) | Crude OR (95%CI) | P value | Adjusted OR (95%CI) | P value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Acetaminophen use during the last year | |||||||||||
| once or less use | 21(14.50) | 158(40.51) | reference | reference | |||||||
| once per 2 to 3 month | 54(37.24) | 108(27.70) | 3.76(2.15 - 6.60) | <0.001 | 3.35(1.82- 6.17) | <0.001 | |||||
| at least one per month | 70(48.28) | 124(31.80) | 4.24(2.47 - 7.29) | <0.001 | 4.22(2.36 - 7.55) | <0.001 | |||||
| Adjusted variables | - | - | |||||||||
| Antibiotic use in the first year of life | - | - | |||||||||
| No | 47(28.14) | 184(47.42) | - | - | reference | ||||||
| Yes | 120(72) | 204(52.60) | - | - | 1.72(1.10 - 2.70) | 0.01 | |||||
| History of asthma in first degree relatives | - | - | |||||||||
| No | 167(97.13) | 368(91.77) | - | - | reference | ||||||
| Yes | 43(21) | 33(8.23) | - | - | 3.85(2.03 - 7.30) | <0.001 | |||||
| History of allergic disorders in second degree relatives | - | - | |||||||||
| No | 100(48.31) | 233(58.10) | - | - | reference | ||||||
| Yes | 107(51.70) | 168(42) | - | - | 1.49(0.98 - 2.30) | 0.06 | |||||
| Number of older siblings | - | - | |||||||||
| 0 | 135(65.53) | 237(59.25) | - | - | reference | ||||||
| 1 | 56(27.18) | 103(25.75) | - | - | 0.65(0.17 - 0.63) | 0.09 | |||||
| 2≤ | 15(7.28) | 60(15.00) | - | - | 0.23(0.10 - 0.52) | <0.001 | |||||
| Number of younger siblings | - | - | |||||||||
| 0 | 182(88.78) | 303(75.94) | - | - | reference | ||||||
| 1≤ | 23(11.22) | 96(24.06) | - | - | 0.33(0.17 - 0.63) | 0.001 | |||||