Table 3:
25(OH) Vitamin D levels in offspring and controls, by genotype
| SNP, locus | 25(OH) Vitamin D (nmol/L); mean (95% CI) | p value* | |
|---|---|---|---|
| Offspring | Controls | ||
| rs2060793, CYP2R1 | < 0.001† | ||
| Wildtype/wildtype | 61.8 (59.9–63.8) | 68.7 (65.7–71.8) | < 0.001 |
| Wildtype/variant | 64.7 (62.7–66.6) | 68.3 (65.7–71.0) | 0.03 |
| Variant/variant | 69.4 (65.8–73.3) | 72.9 (68.4–77.6) | 0.2 |
| rs2282679, GC | < 0.001† | ||
| Wildtype/wildtype | 67.2 (65.2–69.0) | 72.8 (70.2–75.6) | 0.001 |
| Wildtype/variant | 62.6 (60.6–64.7) | 66.1 (63.4–68.9) | 0.05 |
| Variant/variant | 53.1 (50.1–56.1) | 60.3 (55.9–65.0) | 0.04 |
| rs3829251, NADSYN1 | 0.8† | ||
| Wildtype/wildtype | 63.8 (62.2–65.2) | 68.6 (66.4–70.7) | 0.001 |
| Wildtype/variant | 64.8 (62.1–67.6) | 70.1 (66.3–74.2) | 0.05 |
| Variant/variant | 62.4 (55.4–70.2) | 68.3 (59.9–78.5) | 0.3 |
Note: CI = confidence interval, SNP = single nucleotide polymorphism.
*
Analyses were adjusted for age, sex, body mass index, month of the year that blood was drawn (except rs3829251, because the number of participants with the variant/variant genotype was too low), vitamin D use, multivitamin supplement use, and habitual vitamin D intake per day.
†
Pooled p value (offspring and controls) of the association between the genetic variant and vitamin D level.