Skip to main content
. Author manuscript; available in PMC: 2013 Nov 12.
Published in final edited form as: Angew Chem Int Ed Engl. 2012 Oct 12;51(46):11463–11467. doi: 10.1002/anie.201206231

Table 2.

Exploration of Diverse N-terminal Fragments and the Discovery of the Benzamide Fragment

graphic file with name nihms422813u2.jpg
# R IC50 (μM) [a] (10%DMSO)
16 graphic file with name nihms422813t16.jpg 38 ± 3
17 graphic file with name nihms422813t17.jpg 330 ± 10
18 graphic file with name nihms422813t18.jpg >1000
19 graphic file with name nihms422813t19.jpg >1000
20 graphic file with name nihms422813t20.jpg 280 ± 40
21 graphic file with name nihms422813t21.jpg >1000
22 graphic file with name nihms422813t22.jpg 372 ± 7
23 graphic file with name nihms422813t23.jpg 300 ± 50
24 graphic file with name nihms422813t24.jpg 52 ± 2
[a]

IC50 values determined by the displacement of FAM-DEALA-Hyp-YIPD from VCB, with SEM reported.

[b]

Literature value.[18]