Table 2.
Exploration of Diverse N-terminal Fragments and the Discovery of the Benzamide Fragment
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---|---|---|
# | R | IC50 (μM) [a] (10%DMSO) |
16 |
![]() |
38 ± 3 |
17 |
![]() |
330 ± 10 |
18 |
![]() |
>1000 |
19 |
![]() |
>1000 |
20 |
![]() |
280 ± 40 |
21 |
![]() |
>1000 |
22 |
![]() |
372 ± 7 |
23 |
![]() |
300 ± 50 |
24 |
![]() |
52 ± 2 |
IC50 values determined by the displacement of FAM-DEALA-Hyp-YIPD from VCB, with SEM reported.
Literature value.[18]