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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Immunol Invest. 2012;41(6-7):614–634. doi: 10.3109/08820139.2012.680634

Figure 2. Control of T cell translation by MDSC.

Figure 2

Metabolism of L-arginine by MDSC leads to a decrease in the extra cellular availability of arginine, which in T cells activates GCN2 kinase, thereby leading to the phosphorylation of eIF2a. This leads to a global decrease in translation and to the low expression of mRNA stabilizing protein HuR.