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Schematic depiction of liver targeting of MSCs through intrasplenic injection. GFP-transgenic mouse bone marrow derived MSCs, which are positive for GFP, Sca-1, Cxcr4, and Abcc6, were injected through spleen 24 hours after partial hepatecotomy inducing release of SDF-1, a ligand of Cxcr4. The presence of transplanted cells was observed by a live imaging system at day 7 posttransplantation through ventral view (liver) and dorsal view (spleen).
