Skip to main content
. Author manuscript; available in PMC: 2013 Oct 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2012 Aug 10;264(2):192–201. doi: 10.1016/j.taap.2012.08.001

Fig. 1.

Fig. 1

Hepatic glutathione and APAP protein adducts in dose response study of TFP in APAP toxicity in the mouse. Mice were treated with TFP (5.0, 7.5, or 10 mg/kg by oral gavage) 1 h prior to APAP (200 mg/kg IP) and sacrificed at 1 or 2 h. A. Depletion of hepatic glutathione (GSH) in APAP and APAP/TFP mice at 1 and 2 h compared to saline mice (*p<0.05). B. APAP protein adducts in liver in APAP and APAP/TFP mice compared to saline mice (*p<0.05). No differences were detected in adduct levels among the three doses of TFP.