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. Author manuscript; available in PMC: 2012 Dec 11.
Published in final edited form as: Adv Mater. 2008 Mar;20(5):933–938. doi: 10.1002/adma.200701205

Figure 3. Microneedle insertion and protein delivery into skin.

Figure 3

(A) Fluorescence microscopy image of a PVP polymer microneedle with encapsulated sulforhodamine inserted into porcine skin. (B) Brightfield microscopy image of the same skin section after microneedle removal showing the depth of microneedle insertion, stained with hemotoxilin and eosin. (C) Fluorescence microscopy image showing delivery of fluorescently labeled bovine serum albumin by PVP polymer microneedles to porcine skin. (D) Brightfield microscopy image of delivery of enzymatically active β-galactosidase via PVP polymer microneedles to porcine skin. The blue color represents the enzymatic conversion of X-gal by the delivered β-galactosidase