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. 2012 Aug 29;32(12):2181–2192. doi: 10.1038/jcbfm.2012.124

Figure 1.

Figure 1

Levels of protein expression and basal protein phosphorylation of αCaMKII and glutamate receptor expression in the cortex and striatum of Spontaneously Hypertensive (SHR), Wistar Kyoto (WKY), and Sprague-Dawley (SD) rats. (A) Total GluA1, (B) phospho-Ser831-GluA1, (C) total GluN2B, (D) phospho-Ser1303-GluN2B, (E) total αCaMKII, (F) phospho-Thr286-αCaMKII, and (G) phospho-Thr253-αCaMKII expression in the striatum and cortex of SHR, WKY, and SD rats. The striatum and sensory cortex were dissected from male 15-week-old rats (n=6), homogenized, and examined for GluA1, GluN2B, and αCaMKII expression/basal phosphorylation by western blotting. Total protein expression is shown per mg total tissue protein, whereas phosphorylation levels are normalized to total protein expression (i.e., phosphorylation/total expression). * denotes statistical significant difference from the same region compared with SHRs as determined by one-way analysis of variance (ANOVA) (*P<0.05; **P<0.01). CaMKII, calcium/calmodulin-stimulated protein kinase II.