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. 2012 Sep 12;32(12):2201–2210. doi: 10.1038/jcbfm.2012.133

Figure 2.

Figure 2

Liraglutide reduced brain edema and improved neurologic functions at 24, 48, and 72 hours following intracerebral hemorrhage (ICH). Liraglutide was administered 1 hour after immunohistochemistry (IHC) in 75 μg/kg body weight twice daily (LIR 75) or 300 μg/kg body weight twice daily (LIR 300). Brain edema at 24 and 72 hours (A) following operation in sham, vehicle, LIR 75, LIR 300, compound C (CC; 2 mg/kg four times daily) and exendin 9-39 (Ex; 175 μg/kg four times daily). The brain sections (4 mm) were divided into four parts: ispilateral basal ganglia (Ipsi-BG), ispilateral cortex (Ipsi-CX), contralateral basal ganglia (Cont-BG), contralateral cortex (Cont-CX). Cerebellum (Cerebel) is the internal control. Modified Garcia test (B) and wire hanging test (C) at 24, 48, and 72 hours following ICH. Error bars represent mean±standard error of the mean (A) or median±25th to 75th percentiles (B, C). #P<0.01 versus sham; *P<0.05 versus vehicle, **P<0.01 versus vehicle. GLP, glucagon-like peptide.