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. 2012 Dec 10;7(12):e50767. doi: 10.1371/journal.pone.0050767

Figure 1. Effects of MPO inhibition on atherosclerosis in ApoE−/− mice fed on HFD.

Figure 1

A. Images of aortic sinus stained with H&E staining and Masson's trichrome staining from HFD fed ApoE−/− mice treated with placebo (a and d) as control or low dose (b and e) or high dose (c and f) of INV-315. B. Collagen content in plaque in 3 groups by Masson-trichrome staining, expressed as percent of collagen area relative to total sinus area or plaque area. Data are mean± S.E.M. C and D. Box plot of plaque burden quantified by absolute plaque area (C) and percent of plaque area relative to sinus area (D). The box represents the upper and lower quartiles. The whiskers show the 25 and 75 percentiles, and the line in the box represents the median. P<0.05, ** P<0.01 compared with control group. Data from 7–9 different mice.