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. 2012 Dec 10;7(12):e50767. doi: 10.1371/journal.pone.0050767

Figure 2. Effect of MPO inhibition on vascular dysfunction in ApoE−/− mice fed on HFD.

Figure 2

A and B. Representative traces showing acetylcholine (ACh)-induced relaxations in phenylephrine (Phe)-contracted abdominal arterial rings (A) and ACh-induced contractions of abdominal arterial rings in presence of L-NAME (B) from HFD fed ApoE−/− mice treated with placebo as control (a) or low dose (b) or high dose (c) of MPOi. C–H, Concentration-response curves in abdominal arterial rings for ACh without (C) and with (D) L-NAME treatment, phenylephrine with (F) and without (E) L-NAME treatment, SNP (G) and Angiotensin II (H). *P<0.05, **P<0.01, *** P<0.001 indicates significant difference when INV-315 low dose group compared with control group or compared with control group at respective concentration; #P<0.05, ##P<0.01 indicates significant difference when INV-315 high dose group compared with control group or compared with control group at respective concentration. Data are mean± S.E.M. from 5 different mice.