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. 2012 Dec 10;7(12):e50767. doi: 10.1371/journal.pone.0050767

Figure 5. Effects of MPO inhibition on HDL transporting cholesterol and leukocyte adhesion/rolling flux.

Figure 5

A. Effects of MPO inhibition on HDL transporting cholesterol from J774 macrophage cells into medium. *P<0.05, compared with control group. Data are mean± S.E.M. of 5–8 experiments from different mice. B. Representative images of adherent leukocytes in the cremasteric microcirculation (cells with arrow heads indicate adherent monocytes, cells without arrow heads indicate rolling leukocytes) via intra-vital microscopy in C57BL/6 mice with different treatment. a, blank control group; b, INV-315treated control; c, TNFα-treated group; d, TNFα-treated groups with INV-315 pretreatment. C and D, Leukocyte adhesion and leukocyte rolling flux in cremasteric microcirculation via intra-vital microscopy in C57BL/6 mice with different treatment. #P<0.05 compared with TNFα treated group. Data are mean ± SD of 5 different mice, 5–10 experiments from each animal.