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. 2012 Dec 10;7(12):e50086. doi: 10.1371/journal.pone.0050086

Table 4. Analysis of association of POLG1 intronic haplotypes with PD in an independent case-control sample.

Genotype frequency Allele frequency
SNP1 Location N2 Genotype p-value3 OR(95%CI)4 Allele p-value5 OR(95%CI)4
Intron11 GG G/A AA A
c.2070-64G>A cases 110 0.245 0.482 0.273 0.021 1.921(1.098–3.363) 0.499 0.00058 1.896(1.315–2.735)
controls 130 0.384 0.515 0.101 0.358
Intron11 TT T/A AA A
c.2070-12T>A Cases 110 0.245 0.482 0.273 0.021 1.921(1.098–3.363) 0.499 0.00058 1.896(1.315–2.735)
Controls 130 0.384 0.515 0.101 0.358
Intron19 AA A/G GG G
c.3105-36A>G Cases 110 0.227 0.472 0.301 0.076 1.680(0.944–2.991) 0.537 0.0063 1.654(1.152–2.376)
controls 130 0.330 0.515 0.155 0.412
Intron19 TT T/C CC C
c.3105-11T>C Cases 110 0.227 0.472 0.301 0.076 1.680(0.944–2.991) 0.537 0.0063 1.654(1.152–2.376)
controls 130 0.330 0.515 0.155 0.412
1

SNP name for genotype in cases and controls.

2

Number of valid subjects who were successfully genotyped for each of SNP.

3

Analysis performed by a 2×2 table for each SNP using major homozygotes vs. others in cases and controls.

4

Reference group (controls) designated with an OR of 1.00.

5

Analysis performed by a 2×2 table for the number of each allele in cases and controls.