Figure 3. Effect of GABA_AR blockade on the firing pattern of subicular cells.

A: Current-clamp recordings showing the effect of GABA_AR blockade by picrotoxin (100 µM) on the firing modality of an IB, an RS and an IN. Cells were held at V_h = −70 mV and depolarized by intracellular injection of 500 ms current pulses (range 0.02–0.26 nA,). Note that, within PCs, only the IB cell changed its firing modality, whereas the same experimental protocol released steady fast-spiking activity of the IN. B: Effect of picrotoxin (100 µM) on the intrinsic properties of PCs and INs.