Table 2. EMT-core list of 130 genes shared between at least 10 GES datasets.
Upregulated | Downregulated | |
Cell adhesion and migration | ADAM12, CDH11, CDH2, COL1A1, COL3A1, COL5A1, COL6A1, COL6A3, CTGF, CYP1B1, DLC1, FBLN1, FBLN5, FGF2, FGFR1, FN1, HAS2, LUM, MMP2, MYL9, NID2, NR2F1, NRP1, PLAT, PPAP2B, PRKCA, RECK, SERPINE1, SERPINE2, SPOCK1, TGM2, TNFAIP6, TPM1, VCAN, WNT5A | CD24, CDH1, CXADR, CXCL16, DSG3, ELF3, EPCAM, EPHA, JUP, MPZL2, OVOL2, PLXNB1, S100P, SLC7A5, SYK |
Development, cell differentiation and proliferation | CDKN2C, EMP3, FBN1, IGFBP3, IL1R1, LTBP1, MME, PMP22, PTGER2, PTX3, SRGN, SULF1, SYNE1, TAGLN, TUBA1A, VIM, ZEB1 | ABLIM1, ADRB2, ALDH1A3, ANK3, BIK CA2, CTSL2, FGFR2, FGFR3, FST, GJB3, IFI30, IL18, KLK7, KRT15, KRT17, LSR, MAP7, MBP, OCLN, PKP2, PPL, PRSS8, RAPGEF5, SPINT1 |
Angiogenesis and wound healing | DCN, LOX, TFPI | no gene with a major classification * |
Metabolism | ABCA1, GALNT10, SLC22A4 | GPX3, SLC27A2, SMPDL3B, SORL1, ST6GALNAC2 |
Others or unclassified | C5orf13, CDK14, EML1, FSTL1, LTBP2, MAP1B, RGS4, SYT11, TMEM158 | AGR2, C10orf10, CDS1, FAM169A, FXYD3, KLK10, LAD1, MTUS1, PLS1, PRRG4, RHOD, SERPINB1, SLPI, TMEM30B, TPD52L1, TSPAN1, ZHX2, ZNF165 |
Categories have been chosen according to the GO classifications of the enrichment tools. Genes may be present in more than one category.
see Table S3 for more information.