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. 2012 Dec 10;7(12):e51168. doi: 10.1371/journal.pone.0051168

Figure 1. Demonstration and validation of Cre-excision.

Figure 1

(A) GFP staining of hypothalamic sections from crossbred LepR-cre mice×ROSA-eYFP mice illustrates the cre-excision pattern in the hypothalamus, a’f’ represents rostral (bregma −1) to caudal (bregma −2.5) [51] hypothalamic sections, scale bar = 500 µm. (B) PCR analysis confirmed successful excision of human mutant htt exon1 in leptin receptor-expressing neurons in the hypothalamus, but not in a region (striatum), which lacks leptin receptor-expressing neurons.