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ASML-exosomes and TCR activation. Leukocytes were stimulated as described in Figure 4. Expression of molecules involved in TCR signaling was evaluated by flow-cytometry. Representative examples and mean percent ± SD (3 experiments) of stained cells; significant differences in the presence of ASML-exosomes: *. In the presence of ASML-exosomes activation of lck and TCR downstream kinases of the MAPK pathway is impaired. Both effects are strongly mitigated in the presence of DC.
