Table 2. Differentially methylated type 2 diabetes susceptibility genes.
| Gene | Tissue | CpGs(changed/total) | Probe target ID | Distance to TSS(base pairs) | Type 2diabetic (%) | Non-diabetic(%) | Difference(% points) | P | Padj |
| Monogenetic | |||||||||
| CAV1 | SAT | 1/6 | cg27242945 | 295 | 2.3±0.5 | 3.5±0.3 | −1.2 | 0.01 | 0.7 |
| CIDEC | SAT | 1/2 | cg05684195 | 168 | 54.8±3.4 | 50.0±2.4 | 4.9 | 0.003 | 0.3 |
| HNF4A | Skeletal muscle | 1/2 | cg23834593 | −521 | 84.6±2.8 | 82.4±2.3 | 2.2 | 0.02 | 0.8 |
| HNF4A | SAT | 1/2 | cg19717150 | 437 | 75.2±3.8 | 70.5±3.7 | 4.6 | 0.0003 | 0.02 |
| KLF11 | Skeletal muscle | 1/2 | cg20389709 | 621 | 12.7±13.4 | 9.6±9.6 | 3.1 | 0.04 | 0.9 |
| Common variety | |||||||||
| ADCY5 | SAT | 1/2 | cg13384396 | −285 | 14.2±2.5 | 11.7±2.1 | 2.6 | 0.03 | 1.0 |
| CDKN2A | Skeletal muscle | 1/9 | cg07752420 | 11.7±2.9 | 13.1±2.3 | −1.4 | 0.04 | 0.9 | |
| CDKN2A | SAT | 2/9 | cg10895543 | 5.4±0.6 | 6.0±0.8 | −0.6 | 0.04 | 1.0 | |
| CDKN2A | SAT | 2/9 | cg12840719 | 12.6±1.9 | 16.6±2.1 | −4.0 | 0.0003 | 0.02 | |
| CDKN2B | SAT | 4/10 | cg19481686 | 52.4±12.4 | 44.7±9.7 | 7.7 | 0.02 | 0.9 | |
| CDKN2B | SAT | 4/10 | cg08390209 | 54.9±8.3 | 50.0±7.0 | 4.9 | 0.008 | 0.6 | |
| CDKN2B | SAT | 4/10 | cg04675937 | 56.2±10.9 | 48.2±7.3 | 8.0 | 0.03 | 0.9 | |
| CDKN2B | SAT | 4/10 | cg18979223 | 58.4±8.8 | 53.5±5.5 | 4.9 | 0.04 | 1.0 | |
| DUSP9 | Skeletal muscle | 1/1 | cg13915726 | 321 | 33.9±12.8 | 24.6±9.1 | 9.3 | 0.01 | 0.6 |
| DUSP9 | SAT | 1/1 | cg13915726 | 321 | 20.0±13.4 | 27.5±14.6 | −7.6 | 0.009 | 0.6 |
| HHEX | Skeletal muscle | 1/2 | cg11378840 | 85 | 6.4±2.8 | 4.3±1.9 | 2.0 | 0.046 | 0.9 |
| IDE | SAT | 1/2 | cg22812892 | 247 | 1.6±0.2 | 1.3±0.1 | 0.3 | 0.03 | 1.0 |
| IRS1 | SAT | 1/2 | cg11620807 | 122 | 4.0±0.3 | 4.1±0.4 | −0.1 | 0.04 | 1.0 |
| KCNQ1 | Skeletal muscle | 1/23 | cg17820828 | 52.1±11.1 | 55.5±10.7 | −3.4 | 0.04 | 0.9 | |
| KCNQ1 | SAT | 1/23 | cg19728223 | 18.7±9.0 | 11.6±3.9 | 7.2 | 0.05 | 1.0 | |
| MTNR1B | SAT | 1/2 | cg15842276 | −141 | 36.8±6.9 | 35.3±6.9 | 1.5 | 0.01 | 0.7 |
| PPARGC1A | Skeletal muscle | 1/2 | cg04893087 | −383 | 13.9±6.2 | 9.0±4.5 | 5.0 | 0.03 | 0.9 |
| SLC30A8 | Skeletal muscle | 1/2 | cg07459489 | −174 | 69.1±5.0 | 73.9±4.0 | −4.8 | 0.01 | 0.5 |
| TSPAN8 | SAT | 1/2 | cg12965512 | −557 | 46.6±6.6 | 39.2±7.9 | 7.3 | 0.04 | 1.0 |
| WFS1 | SAT | 1/2 | cg09785172 | 81 | 1.8±0.3 | 2.1±0.4 | −0.3 | 0.04 | 1.0 |
The microarray included in total 49 type 2 diabetes candidate genes represented by 136 probes. Each CpG site is identified with Illumina probe target ID. The CpG site location is given as the base pair distance to transcription start site (TSS) if available. Data are shown as mean±standard deviation. P adj-values are corrected for multiple testing (136 tests).