Table 3. Statistically significant molecular and immunohistochemical parameters.
| Group | Total Case | TCRP1 IHC Scores | MT1X IHC Scores | ||||||
| − | + | ++ | +++ | − | + | ++ | +++ | ||
| Resistant | 30 | 5 | 4 | 11 | 10 | 4 | 3 | 13 | 10 |
| Sensitive | 30 | 11 | 10 | 7 | 2 | 11 | 12 | 4 | 3 |
| a TCRP1 P = 0.005 | a MT1X P = 0.000 | ||||||||
| bResistent group: r = 0.990,P = 0.01 Sensitive group: r = 0.886,P = 0.114 | |||||||||
Clinical samples from primary oral squamous cell carcinoma were classified into cisplatin-resistant and cisplatin-sensitive groups on the basis of MTS assays as described in Materials and Methods.
a
Mann–Whitney U test was used to compare the differences in TCRP1 and MT1X with varying degrees of IHC Scores (−, +, ++, +++) between the resistant and sensitive groups. P-values for statistical significance are indicated.
b
Spearman’s correlation coefficient was used to analyze whether the relationships between expression of TCRP1 and MT1X in primary tumors correlate with their drug resistance patterns. P<0.05 was considered statistically significant.