Table 2. HIV- and non HIV-related factors influencing suPAR levels.
| Univariate | Multiple | |||||
| Variables | % Estimate (95% CI) | P | N | % Estimate (95% CI) | P | N |
| Demography | ||||||
| Age ≥60 vs. <40 years | 20.0 (10.6; 30.2) | <0.001 | 992 | 19.1 (9.4; 30.0) | <0.001 | 992 |
| Age ≥60 vs. 40–50 years | 9.3 (1.0; 18.3) | 8.4 (0.1; 17.4 ) | ||||
| Age ≥60 vs. 50–60 years | 5.2 (−3.6; 14.8) | 4.7 (−4.0; 14.3) | ||||
| Sex (men vs. women) | −1.8 (−6.9; 3.7) | 0.52 | 992 | −7.1 (−12.8; −1.1) | 0.02 | 992 |
| European descent | 10.1 (4.4; 16.3) | <0.001 | 992 | 9.8 (3.1; 17.0) | 0.004 | 992 |
| HIV-related | ||||||
| HIV duration (years) | 0.5 (0.1; 0.8) | 0.01 | 992 | 0.1 (−0.3; 0.5) | 0.75 | 992 |
| Nadir CD4+ (cells/µL)* | 0.01 (−0.01; 0.02) | 0.44 | 959 | −0.01 (−0.02; 0.01) | 0.62 | 958 |
| No current cART* | 9.0 (2.2; 16.2) | 0.009 | 990 | 17.3 (8.0;27.4) | <0.001 | 958 |
| Treatment duration (years)** | 0.3 (−0.4; 1.0) | 0.43 | 861 | −1.4 (−2.3; −0.4) | 0.006 | 845 |
| CD4<350 vs. 350≥cells/µL*** | 9.1 (2.8; 15.6) | 0.004 | 949 | 6.6 (−0.1; 13.8) | 0.05 | 907 |
| VL, cART-treated patients (pr. 10-fold)*** | 18.9 (11.8; 26.5) | <0.001 | 794 | 20.5 (13.1; 28.4) | <0.001 | 779 |
| VL, for untreated patients (pr. 10-fold)*** | 3.7 (−6.0; 14.5) | 0.46 | 146 | 2.4 (−8.7; 14.9) | 0.68 | 128 |
| Lifestyle | ||||||
| Daily vs. no daily smoking | 26.4 (18.3; 35.1) | <0.001 | 428 | 26.7 (18.6; 35.4) | <0.001 | 428 |
| Waist circumference (cm)# | 0.2 (−0.04; 0.5) | 0.09 | 415 | 0.3 (0.02; 0.6) | 0.03 | 408 |
| BMI <20 vs. 20–25 (kg/m2)## | 2.9 (13.2; 6.5) | 0.01 | 483 | −0.8 (−8.8; 11.4) | 0.07 | 408 |
| BMI <20 vs. 25–30 (kg/m2)## | 11.9 (1.0; 23.9) | 7.5 (−5.3; 22.0) | ||||
| BMI <20 vs. ≥30 (kg/m2)## | −5.8 (−17.6; 7.9) | −6.6 (−22.4; 12.4) | ||||
| Metabolic syndrome# | 6.6 (−1,8; 15.8) | 0.13 | 366 | 8.4 (0.2; 17.2) | 0.04 | 338 |
All multiple analyses are adjusted for sex, age, and European descent.
*
Multiple analyses are also adjusted for time since HIV-diagnosis.
**
Multiple analyses are also adjusted for time since HIV-diagnosis, current treatment and nadir CD4+ cell counts.
***
Multiple analyses are also adjusted for time since HIV-diagnosis, nadir CD4+ cell counts, current treatment, CD4+<350 vs. ≥350 cells/µL, and log10(VL).
#
Multiple analyses are also adjusted for daily smoking.
##
Multiple analyses are also adjusted for daily smoking, waist circumference.
Abbreviations: cART: Combination antiretroviral treatment; VL: viral load; BMI: Body mass index; CI: Confidence interval.