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. 2012 Dec 10;7(12):e51478. doi: 10.1371/journal.pone.0051478

Figure 6. Network of direct and indirect Bcl-3 target genes during unloading.

Figure 6

Display of ChIP-Array data from a comparison of 2,817 Bcl-3 binding peaks increased in unloading over controls vs. 3,334 genes with increased expression in unloaded muscles. A blue circle indicates the location of Bcl-3. Projections from Bcl-3 in yellow are the direct targets including 5 direct transcription factor target genes, which are indicated in pink circles. Projections from pink targets are indirect Bcl-3 targets indicated in gray. Thus, ChIP-Array found 241 direct targets, 5 direct targets with indirect targets (the transcription factors) and 305 indirect target genes of Bcl-3 in the gene expression array data. The direct targets are those from the Bcl-3 ChIP-seq list with some not identified because of gene name terminology differences in the ChIPArray format. However the direct targets with indirect targets yields important evidence for a hierarchy of gene regulation.