Table 1.
Genotypic and allelic frequencies of the MDM2 SNP285 and SNP309 in BRCA related ovarian cancer, sporadic ovarian cancer and healthy controls
| |
SNP285 |
BRCA1 related |
BRCA2 related |
Sporadic disease* |
Healthy controls* |
||||
|---|---|---|---|---|---|---|---|---|---|
| n | (%) | n | (%) | n | (%) | n | (%) | ||
| SNP285 |
GG |
153 |
(95.0) |
58 |
(96.7) |
1260 |
(93.7) |
2 274 |
(92.3) |
| |
GC |
8 |
(5.0) |
2 |
(3.3) |
82 |
(6.1) |
183 |
(7.4) |
| |
CC |
0 |
(0.0) |
0 |
(0.0) |
3 |
(0.2) |
8 |
(0.3) |
| |
Total |
161 |
(100) |
60 |
(100) |
1 345 |
(100) |
2 465 |
(100) |
| |
G |
314 |
(97.5) |
118 |
(98.3) |
2 602 |
(96.7) |
4 731 |
(96.0) |
| |
C ** |
8 |
(2.5) |
2 |
(1.7) |
88 |
(3.3) |
199 |
(4.0) |
| SNP309 |
TT |
52 |
(32.3) |
22 |
(36.7) |
515 |
(38.3) |
1 072 |
(43.5) |
| |
TG |
81 |
(50.3) |
32 |
(53.3) |
661 |
(49.1) |
1 093 |
(44.3) |
| |
GG |
28 |
(17.4) |
6 |
(10.0) |
169 |
(12.6) |
300 |
(12.2) |
| |
Total |
161 |
(100) |
60 |
(100) |
1 345 |
(100) |
2 465 |
(100) |
| |
T |
185 |
(57.5) |
76 |
(63.3) |
1 691 |
(62.9) |
3 237 |
(65.7) |
| G ** | 137 | (42.5) | 44 | (36.7) | 999 | (37.1) | 1 693 | (34.3) | |
* Previously published data [28].
** Minor allele.