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. 2012 Dec 10;7(12):e51537. doi: 10.1371/journal.pone.0051537

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© 2012 Hajrezaie et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The negative control group (A) has no injury of gastric mucosa. The ulcer control group (B) shows sever injuries in the gastric mucosa. Absolute ethanol produced extensive visible hemorrhagic necrosis of gastric mucosa. The reference control group (omeprazole, 20 mg/kg) (C) shows mild injuries in the gastric mucosa comparing to the injuries seen in group 2. Rats received 10 mg/kg of the complex (D) has moderate injuries in the gastric mucosa. The extract reduces the formation of gastric lesions induced by absolute ethanol. Rats received 20 mg/kg of the complex (E) shows mild injuries in the gastric mucosa. Rats received 40 mg/kg of the complex (F) shows mild injuries in the gastric mucosa. Rats received 80 mg/kg of the complex (G) does not show any injuries of the gastric mucosa instead flattening of gastric mucosa is visible (white arrow). Black arrows point to the superficial hemorrhagic mucosal lesions.