Table 2. Cortical thickness comparisons child sample.
Contrast | Cortical region | Hemisphere | Talairach | Size | pmax | ||
X | Y | Z | (mm2) | ||||
All ADHD vs Control | |||||||
Control>ADHD | Inferior Parietal* | L | −47.4 | −58.1 | 41.0 | 7817.34 | 1.16E-07 |
Superior Parietal* | |||||||
Cuneus* | |||||||
Inferior Parietal* | R | 36.1 | −74.6 | 33.1 | 12932.79 | 4.80E-10 | |
Superior Parietal* | |||||||
Cuneus | |||||||
Lateral Occipital | |||||||
Middle Temporal | |||||||
Lingual* | |||||||
Fusiform | |||||||
Lingual* | L | −6.3 | −80.8 | 0.2 | 3190.14 | 1.98E-05 | |
Fusiform | |||||||
Precentral* | L | −39.0 | −5.4 | 54.0 | 2126.83 | 1.27E-06 | |
Superior Frontal* | |||||||
Caudal Middle Frontal | |||||||
Precentral* | R | 46.5 | −5.2 | 44.4 | 2797.57 | 2.70E-06 | |
Superior Frontal* | |||||||
Orbitofrontal * | L | −35.1 | 38.1 | −10.4 | 5547.78 | 2.79E-06 | |
Rostral Middle Frontal* | |||||||
Inferior Frontal | |||||||
Orbitofrontal | R | 19.6 | 60.4 | −3.3 | 2421.24 | 2.14E-05 | |
Rostral Middle Frontal | |||||||
Control<ADHD | - | ||||||
Medicated ADHD vs Control | |||||||
Control>ADHD | Inferior Parietal* | L | −47.4 | −58.1 | 41.0 | 7577.90 | 2.12E-07 |
Superior Parietal* | |||||||
Precuneus | |||||||
Cuneus | |||||||
Superior Frontal | |||||||
Inferior Parietal* | R | 36.1 | −74.6 | 33.1 | 12534.43 | 3.99E-10 | |
Superior Parietal* | |||||||
Superior Frontal* | |||||||
Cuneus | |||||||
Lateral Occipital | |||||||
Inferior Temporal | |||||||
Lingual* | |||||||
Fusiform | |||||||
Lingual* | L | −7.6 | −81.6 | −0.3 | 2654.72 | 7.33E-05 | |
Fusiform | |||||||
Precentral* | L | −38.4 | −5.5 | 53.6 | 2767.74 | 2.17E-06 | |
Postcentral | |||||||
Orbitofrontal* | L | −35.3 | 37.5 | −10.2 | 2677.03 | 5.96E-06 | |
Rostral Middle Frontal | |||||||
Superior Frontal | |||||||
Inferior Frontal | |||||||
Orbitofrontal | R | 9.1 | 29.9 | −19.2 | 1451.53 | 1.91E-04 | |
Rostral Middle Frontal | |||||||
Control<ADHD | - |
Full results of the ‘control>ADHD’ comparison in the child groups including all ADHD subjects. The second section of the table provides the results of the same comparisons including only those patients with a history of pharmacological treatment with psychostimulant medication. Results are thresholded at p<0.05, MCTSB corrected for multiple comparisons. No clusters of thicker cortical mantle were observed in the ADHD sample compared to the control children (contrast ‘control<ADHD’).
Clusters in these regions also survive a threshold of p<0.001, MCTSB corrected for multiple comparisons.