Table 4.
Summary of cagA and vacA s, m, and i genotypes in relation to peptic ulcer disease and gastric cancer risk
| |
|
|
|
cagA genotype |
vacA genotype |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Disease | Paper (n) | Patient (n) | cagA (n/%) | Western EPIYA-ABC | East-Asian EPIYA-ABD | s1 (n/%) | s1a (n/%) | s1b (n/%) | s1c (n/%) | s2 (n/%) | m1 (n/%) | m2 (n/%) | s1m1 (n/%) | s1m2 (n/%) | s2m1 (n/%) | s2m2 (n/%) | i1 (n/%) | i2 (n/%) |
| NUD |
8 |
604 |
555 (92) |
127 (44) |
160 (56) |
414 (99) |
62 (63) |
4 (4) |
33 (33) |
4 (1) |
224 (55) |
185 (45) |
224 (55) |
180 (44) |
0 (0) |
4 (1) |
186 (94) |
11 (6) |
| PU |
8 |
279 |
264 (95) |
11* (21) |
42 (79) |
236 (100) |
38 (64) |
1 (2) |
20 (33) |
1 (0) |
135 (59) |
92 (41) |
134 (59) |
92 (41) |
0 (0) |
1 (0) |
40 (100) |
0 (0) |
| GC |
5 |
74 |
73 (99) |
9* (17) |
45 (83) |
42 (100) |
2 (67) |
0 (0) |
1 (33) |
0 (0) |
22 (54) |
19 (46) |
22 (54) |
19 (46) |
0 (0) |
0 (0) |
22 (100) |
0 (0) |
| Total | 957 | 892 (93) | 147 (37) | 247 (63) | 692 (99) | 102 (63) | 5 (3) | 54 (34) | 5 (1) | 380 (56) | 296 (44) | 380 (56) | 291 (43) | 0 (0) | 5 (1) | 248 (96) | 11 (4) | |
*: p < 0.05 (significantly different prevalence compared with NUD) by use of chi-square test.