Table 3.
Pooled ORs of association between TNF-238G/A polymorphism and TB susceptibility
|
Comparison |
Cases/Controls |
GA+AA versus GG |
A versus G |
||||
|---|---|---|---|---|---|---|---|
| OR(95% CI) | Pz test | Ph | OR(95% CI) | Pz test | Ph | ||
|
Ethnicity |
|
|
|
|
|
|
|
|
Asian |
800/625 |
1.124 (0.792–1.597) |
0.639 |
0.513 |
0.513 (0.799–1.567) |
0.538 |
0.513 |
|
Non-Asian |
384/914 |
0.844 (0.542-1.313) |
0.451 |
0.698 |
0.837 (0.544-1.287) |
0.417 |
0.687 |
|
TB type |
|
|
|
|
|
|
|
|
PTB |
644/731 |
1.037 (0.708-1.517) |
0.853 |
0.487 |
0.993 (0.689-1.431) |
0.971 |
0.428 |
|
Other TB |
359/275 |
1.259 (0.698-2.271) |
0.443 |
0.878 |
1.334 (0.755-2.358) |
0.321 |
0.856 |
|
HIV status |
|
|
|
|
|
|
|
|
HIV- |
515/835 |
1.003 (0.688–1.462) |
0.989 |
0.446 |
1.034 (0.719–1.487) |
0.855 |
0.375 |
| ND | 669/704 | 1.007 (0.679-1.493) | 0.973 | 0.634 | 0.964 (0.661-1.407) | 0.850 | 0.584 |
*Ph= Pheterogeneity; HIV-= HIV negative; PTB= pulmonary tuberculosis; ND= Not done.