Table 4. SBI Genotyping on human and bovine isolates of EHEC O157.
SBI Genotype Codinga | Bovine (%) | Human (%) | Total (%) | SBI Genogroupb | P-valueb | Former SBI genotype designation (%)c |
WY12 | 92 (40.5) | 97 (50.5) | 189 (45.1) | CG | 0.048 | 3 (91), 7 (6.4), 18 (2.1), 22 (0.5) |
AY2 | 11 (4.8) | 47 (24.5) | 58 (13.8) | CG | <0.0001 | 1 (96.6), 19 (3.5) |
SY2c | 45 (19.8) | 2 (1.0) | 47 (11.2) | BBG | <0.0001 | 5 (87.2), 1 (10.6), 19 (2.1) |
ASY12c | 38 (16.7) | 8 (4.2) | 46 (11.0) | BBG | <0.0001 | 6 (100) |
ASY22c | 5 (2.2) | 15 (7.8) | 20 (4.8) | CG | 0.01 | 1 (85), 5 (15) |
SY12c | 14 (6.2) | 0 (0.0) | 14 (3.3) | BBG | 0.0004 | 6 (92.9), 16 (7.1) |
ASY2 | 1 (0.4) | 12 (6.3) | 13 (3.1) | CG | 0.0005 | 1 (100) |
W2 | 3 (1.3) | 8 (4.2) | 11 (2.6) | Unclassified | 0.12 | 4 (100) |
WY2 | 4 (1.8) | 0 (0.0) | 4 (1.0) | Unclassified | N/A | 2 (100) |
Y | 4 (1.8) | 0 (0.0) | 4 (1.0) | Unclassified | N/A | 17 (75), 10 (25) |
ASY2c | 2 (0.9) | 0 (0.0) | 2 (0.5) | Unclassified | N/A | 5 (100) |
AWY12 | 1 (0.4) | 1 (0.5) | 2(0.5) | Unclassified | N/A | 3, 18 |
AY | 1 (0.4) | 0 (0.0) | 1 (0.2) | Unclassified | N/A | 10 (100) |
Y1 | 0 (0.0) | 1 (0.5) | 1 (0.2) | Unclassified | N/A | 8 (100) |
ASY1 | 1 (0.4) | 0 (0.0) | 1 (0.2) | Unclassified | N/A | 13 (100) |
AY1 | 1 (0.4) | 0 (0.0) | 1 (0.2) | Unclassified | N/A | 13 (100) |
WY1 | 1 (0.4) | 0 (0.0) | 1 (0.2) | Unclassified | N/A | 22 (100) |
SWY2c | 1 (0.4) | 0 (0.0) | 1 (0.2) | Unclassified | N/A | 12 (100) |
0 (0.0) | 1 (0.5) | 1 (0.2) | Unclassified | N/A | 9 (100) | |
SY122c | 1 (0.4) | 0 (0.0) | 1 (0.2) | Unclassified | N/A | 6 (100) |
AWY2 | 1 (0.4) | 0 (0.0) | 1 (0.2) | Unclassified | N/A | 2 (100) |
Total | 227 | 192 | 419 |
Concatenation of presence of specific bacteriophage at argW, sbcB, wrbA or yehV locations designated by uppercase first letter of each insertion site (A, S, W or Y,) followed by the presence of stx1, stx2a or stx2c denoted by 1,2 or 2c.
The SBI Genotypes that are significantly over-represented among cattle isolates as compared to human isolates are referred as bovine-biased genotypes (BBG); the SBI Genotypes that show significantly over-representation/similar-representation among human isolates as compared to cattle isolates are referred as clinical genotypes (CG); the SBI genotypes that could not be evaluated for a bovine association due to small numbers (1–4 isolates) are designated “unclassified” genotypes in this manuscript (Fisher’s exact test P≤0.05).