Table 2. Known molecular target candidates for diagnosis and therapy of RA.

Category	Symbol	P Value	Chemical	RA association	Associated Modules
PPI	PTPRC	<0.00001	O	O	T cell activation
	JAK1	<0.00001	O	O	JAK-STAT signaling
	CD19	<0.00001	O	O	B cell activation
	TNF	<0.00001	O	O	Inflammatory cytokines
	CXCR4	<0.00001	O	O	Cell migration and adhesion, Chemokines
	TLR4	<0.00001	O	O	Toll-like receptor signaling
	CD247	<0.00001	O	O	T cell activation, NK cell mediated cytotoxicity
	CCR3	0.00001	O	O	Chemokines
	THBS1	0.00027	O	O	Matrix remodeling
TF	NFKB1	<0.00001	O	O	Matrix remodeling, NK cell mediated cytotoxicity, Cell death and survival, Chemokines
	TP53	<0.00001	O	O	Cell death and survival
	JUN	0.00001	O	O	Matrix remodeling, ECM organization
	FOXP3	0.00009	O	O	T cell activation
	POU2F1	0.00028	O	O	B cell activation
	ETS2	0.00377	O	O	Angiogenic factors, Chemokines