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. 2012 Dec 11;7(12):e51677. doi: 10.1371/journal.pone.0051677

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© 2012 Domaica et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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PBMCs from two healthy normal donors (N1 and N2) and from the patient (P) (A, B) or sorted CD56^dim and CD56^bright NK cells from one healthy normal donor and from the patient (C) were stimulated for 3 days with IL-2. Also, PBMCs from two healthy normal donors (N1 and N2) and from the patient (P) were stimulated for 3 days with IL-15 (D, E). Thereafter, cells were harvested and stained with anti-CD3 and anti-CD56, and a third fluorochrome-labeled mAb (indicated on the y-axis). Also, expression of CD57 and CD158 in NK cells (gated as CD3⁻CD56⁺ cells) from N1, N2 and the patient (P), and on CD3⁻CD56^dim cells from P was plotted for cells stimulated with IL-2 or IL-15 (B, E). Expression of CD57 and CD158 on sorted and IL-2-stimulated CD56^dim NK cells from one healthy normal donor and from the patient is also shown (C). Data are depicted as dot plots. The percentages in each quadrant are shown. Results correspond to one from 3 independent experiments.