Table IV.
Summary of quantitative and frequency of response of EHR antigens including Acr1, CFP-10 and ESAT-6
| Medians (SFC/106 PBMC) (IQR) | Proportion of responders | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IFN-γ | IL-2 | IFN-γ | IL-2 | |||||||||
| Latent | Active | p | Latent | Active | Latent | Active | p | Latent | Active | p | ||
| Acr-1 | 16 (4-40) | 12 (0-70) | 0.59 | 8(0-24) | 8 (0-25) | 0.68 | 33 | 38 | 0.64 | 26 | 30 | 0.78 |
| CFP-10 | 84 (37-234) | 124 (26-408) | 0.87 | 64 (8-184) | 20 (0-140) | 0.06 | 78 | 73 | 0.79 | 68 | 52 | 0.28 |
| ESAT-6 | 72 (28-223) | 123 (43-410) | 0.20 | 52 (13-132) | 32 (10-80) | 0.25 | 73 | 78 | 0.60 | 71 | 63 | 0.58 |
| Rv0188 | 4 (0-25) | 6 (0-23) | 0.55 | NA | NA | NA | 20 | 18 | 1.00 | NA | NA | NA |
| Rv0767 c | 7 (1-38) | 5 (0-23) | 0.44 | 0 (0-4) | 0 (0-8) | 0.87 | 30 | 12 | 0.25 | 12 | 0 | 0.49 |
| Rv0826 | 46 (25-130) | 28 (13-46) | 0.15 | 276 (44-669) | 153 (5-575) | 0.42 | 65 | 35 | 0.11 | 86 | 58 | 0.19 |
| Rv0847 | 12 (0-16) | 6 (0-43) | 0.80 | 0 (0-4) | 0 (0-12) | 0.49 | 10 | 35 | 0.13 | 8 | 0 | 1.00 |
| Rv0849 | 54 (15-76) | 22 (12-68) | 0.19 | 0 (0-7) | 12 (1-44) | 0.05 | 70 | 35 | 0.06 | 14 | 33 | 0.37 |
| Rv0967 | 20 (4-125) | 14 (5-58) | 0.41 | 0 (0-5) | 5 (0-9) | 0.15 | 45 | 30 | 0.51 | 14 | 17 | 1.00 |
| Rv0990c | 32 (4-192 | 46 (11-85) | 0.77 | 5 ( 0-40) | 11 (0-40) | 0.74 | 55 | 59 | 1.00 | 29 | 40 | 0.71 |
| Rv0991c | 12 (4-32) | 4 (0-16) | 0.09 | 0 (0-105) | 0 (0-4) | 0.78 | 30 | 10 | 0.24 | 21 | 8 | 0.60 |
| Rv1284 | 57 (11-286) | 80 (14-168) | 0.89 | 20 (0-53) | 27 (16-52) | 0.34 | 60 | 59 | 1.00 | 53 | 73 | 0.29 |
| Rv1471 | 66 (17-188) | 75 (11-245) | 0.84 | 4 (0-8) | 10 (0-25) | 0.18 | 75 | 59 | 0.48 | 12 | 33 | 0.21 |
| Rv1954c | 60 (20-470) | 72 (27-210) | 0.89 | 4 (0-86) | 10 (0-30) | 0.89 | 70 | 76 | 0.72 | 41 | 33 | 0.73 |
| Rv1955 | 68 (25-367) | 60 (6-151) | 0.29 | 8 (0-104) | 15 (0-32) | 0.63 | 75 | 71 | 1.00 | 47 | 47 | 1.00 |
| Rv1956 | 12 (6-38) | 16 (5-75) | 0.98 | 0 (0-8) | 0 (0-12) | 0.85 | 30 | 35 | 1.00 | 18 | 20 | 1.00 |
| Rv1957 | 48 (18-454) | 136 (45-328) | 0.41 | 0 (0-18) | 5 (0-10) | 0.54 | 65 | 88 | 0.14 | 24 | 20 | 1.00 |
| Rv2021c | 0 (0-7) | 0 (0-0) | 0.02 | Not tested | Not tested | NA | 15 | 0 | 0.23 | NA | NA | NA |
| Rv2022c | 64 (29-228) | 65 (29-124) | 0.66 | 8 (0-30) | 6 (0-15) | 0.58 | 75 | 76 | 1.00 | 29 | 13 | 0.40 |
| Rv2466c | 15 (1-51) | 40 (6-71) | 0.18 | 12 (2-28) | 20 (15-29) | 0.16 | 30 | 53 | 0.19 | 35 | 53 | 0.48 |
| Rv2517c | 4 (0-12) | 0 (0-4) | 0.12 | 0 ( 0-12) | 2 (0-7) | 0.77 | 10 | 10 | 1.00 | 0 | 8 | 0.46 |
| Rv2660c | 14 (1-40) | 6 (0-25) | 0.34 | 0 (0-5) | 4 (0-11) | 0.30 | 30 | 20 | 0.72 | 7 | 8 | 1.00 |
| Rv2662 | 0 (0-0) | 0 (0-0) | 0.91 | Not tested | Not tested | NA | 0 | 0 | NA | NA | NA | NA |
| Rv2663 | 0 (0-0) | 0 (0-0) | 0.84 | Not tested | Not tested | NA | 0 | 0 | NA | NA | NA | NA |
| Rv2664 | 0 (0-0) | 0 (0-0) | 0.35 | Not tested | Not tested | NA | 0 | 0 | NA | NA | NA | NA |
| Rv2693c | 28 (9-102) | 16 (1-56) | 0.16 | 0 (0-4) | 0 (0-10) | 0.72 | 50 | 35 | 0.52 | 7 | 17 | 0.58 |
| Rv2780 | 46 (16-110) | 24 (5-101) | 0.87 | 114 (9-761) | 26 (0-319) | 0.20 | 60 | 45 | 0.53 | 71 | 58 | 0.68 |
| Rv3334 | 0 (0-0) | 0 (0-0) | 0.85 | 0 (0-2) | 0 (0-0) | 0.79 | 5 | 12 | 0.58 | 6 | 0 | 1.00 |
| Rv3406 | 21 (6-290) | 29 (0-106) | 0.59 | 0 (0-2) | 0 (0-10) | 0.36 | 40 | 47 | 0.75 | 12 | 13 | 1.00 |