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. Author manuscript; available in PMC: 2012 Dec 12.
Published in final edited form as: Immunity. 2011 Jun 30;35(1):135–145. doi: 10.1016/j.immuni.2011.05.011

Figure 5. A TLR7-Dependent Mechanism Detects Retroviruses.

Figure 5

(A) WT I/LnJ and Myd88−/− I/LnJ mice were i.p. injected with MMTV. Sera were analyzed for reactivity against MMTV virion proteins by immunoblot 10 weeks after infection.

(B) Sera from RL-MuLV-infected B6 (left) and I/LnJ (right) mice with indicated genotypes were tested for reactivity against MuLV virion proteins by immunoblot 10 weeks after infection. PFU × 102: virus titers in mouse spleens (105 cells) 10 weeks after infection.

(C) WT I/LnJ and Tlr7−/− I/LnJ mice were i.p. injected with MMTV. Sera were analyzed for reactivity against MMTV virion proteins by immunoblot 10 weeks after infection.

Goat anti-mouse Abs coupled to HRP were used at the second step. Numbers correspond to individual mice within a single experiment.