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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Invest Dermatol. 2012 Sep 6;133(2):553–561. doi: 10.1038/jid.2012.326

Figure 3. MSC-FMB correct deficits in gain in WTS caused by WBI.

Figure 3

a) Syngeneic MSC-FMB were implanted in pre-irradiated C57Bl/6 mice and deficit reduction in WTS was assessed after 4 weeks of healing. Mice were exposed to either 18Gy SI or to 6Gy WBI. FMB alone were implanted as a control. b) 1×106 MSC-FMB and 2×106 MSC-FMB were implanted in pre-irradiated wounds of C57Bl/6 and C3H mice. Deficit reduction in WTS was assessed after 4 weeks of exposure to 6 Gy/WBI+ 15Gy SI. Error bars indicate mean+/−SEM, n=4. Significance: *P<0.05, **P<0.01 by Student’s t-test. (WTS: wound tensile strength; WBI: whole body irradiation; SI: Skin only irradiation; MSC: Marrow Stromal Cells; FMB: Fibrin Microbeads; TD: Total deficit)