Table 2.
Clinical characteristics at baseline, 8 weeks and 16 weeks by randomization group.
| Cinacalcet | Paracalcitol | |||||
|---|---|---|---|---|---|---|
| Baseline | 8 weeks | 16 weeks | Baseline | 8 weeks | 16 weeks | |
| Age, years | 53 [48, 54] | 47 [46, 49] | ||||
| BMI, kg/m2 | 33 [28, 36] | 38.8 [26.0, 43.5] | ||||
| Truncal fat, % | 38.9 [30, 46.5]* | 53 [46, 55]* | ||||
| 25 (OH) Vit D, ng/mL | 16 [15, 22] | 35 [27, 46] | 33 [26,39] | 16 [11.5, 28.2] | 30 [28, 38] | 21 [20,28] |
| Parathyroid hormone, pg/mL | 294 (241, 475) | 846 (185, 1012) | 1073 (292, 1527) | 267 (176, 617) | 576 (311, 915) | 498 (225, 855) |
| Calcium, mg/dL | 9.4 [8.8, 9.5] | 8.1 [7.7, 8.2] | 8.2 [7.9, 8.5] | 9.1 [8.4, 9.5] | 8.1 [7.4, 8.3] | 10.0 [9.6, 10.1] |
| Phosphorus, mg/dL | 5.1 [3.9, 6.9] | 4.9 [3.8, 6.2] | 4.9 [4.1, 4.9] | 4.4 [4.2, 7.5] | 5.4 [4.9, 6.0] | 6.3 [5.8, 6.9] |
| Interleukin 6, pg/mL | 5.6 [4.2, 8.5] | 8.1 [7.7, 9.0] | 5.4 [5.1, 11.6,] | 16.2 [10.5, 18.4] | 9.0 [7.7, 9.7] | 7.2 [3.6, 7.6] |
| hsCRP, mg/dL | 2.4 [1.7, 8.6] | 3.7 [2.0, 8.9] | 2.8 [2.5, 9.5] | 6.1 [5.6, 6.2] | 5.3 [3.5, 7.1] | 2.8 [2.6, 8.8] |
| Insulin, mU/L | 11.3 [8.7, 11.6] | 17.9 [8.3, 19.3] | 10.5 [7.6, 12.2] | 13.8 [11.6, 23.2] | 19.8 [14.3, 22.3] | 24.3 [8.2, 24.6] |
| Glucose, mg/dL | 87 [84, 92) | 102 [95, 105] | 85 [84, 87] | 111 [109, 127] | 116 [102, 133] | 121 [102, 124] |
| GDR, mg/kg/min | 6.9 [5.8, 8.6] | 6.7 [5.4, 7.9] | 6.9 [5.7, 8.6] | 4.1 [3.5, 6.4] | 5.0 [3.4, 5.4] | 4.7 [4.2, 4.8] |
| HOMA | 2.4 [1.7, 2.4]* | 4.2 [2.1, 4.8] | 2.1 [1.9, 2.7] | 3.5 [3.2, 7.3]* | 4.9 [4.8, 6.4] | 7.4 [2.5, 7.7] |
| QUICKI | 0.33 [0.33, 0.35] | 0.31 [0.30, 0.34] | 0.34 [0.33, 0.35] | 0.32 [0.29, 0.32] | 0.30 [0.29, 0.30] | 0.29 [0.29, 0.33] |
| HOMA-adiponectin | 44 [41, 59] | 48 [34, 103] | 28 [23, 42] | 76 [54, 140] | 105 [70, 139] | 90 [88, 132] |
| Leptin-adiponectin-ratio | 0.70 [0.60, 0.82] | 0.71 [0.35, 1.58] | 0.42 [0.21, 4.15] | 1.56 [1.15, 4.45] | 2.24 [0.91, 4.26] | 2.10 [0.87, 3.80] |
| Adiponectin, ug/mL | 19 [16, 33] | 20 [19, 34] | 26 [26, 36] | 21 [16, 24] | 25 [17, 26] | 23 [17, 31] |
| Leptin, ng/mL | 19 [12, 68] | 14 [12, 30] | 12.0 [8, 50] | 64 [15, 70] | 74 [13, 77] | 71 [10, 77] |
Except where indicated otherwise, values are the median [interquartile range]
Truncal fat and HOMA were statistically significantly different at baseline with a *p>0.05