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. 2012 Sep 18;20(12):2315–2325. doi: 10.1038/mt.2012.190

Figure 6.

Figure 6

The phenotype of pancreas-associated macrophages and the frequency of regulatory T cells are modified by Alox15 siRNA/IVF2.0 treatment of prediabetic NOD mice. (a) The expression levels of various costimulatory molecules expressed by CD11b+ cells were assessed by flow cytometry in the spleen, pancreatic lymph nodes (PLN), and pancreas of IVF2.0 alone, Alox15-specific or scrambled siRNA/IVF2.0-treated NOD mice. The data represent the frequencies as a mean ± SD of three independent experiments, n = 6. (b) The frequency of CD4+Foxp3+ regulatory T cells (Tregs) was measured in the spleen, PLN, and pancreas of IVF2.0 alone or Alox15 siRNA/IVF2.0-treated NOD mice. Data are representative of two independent experiments and represent the mean ± SD, n = 6. *P < 0.05; **P < 0.01. MHC, major histocompatibility complex; NOD, nonobese diabetic; NT, non-treated; siRNA, small interfering RNA.